{"id":2170,"date":"2013-12-28T21:33:27","date_gmt":"2013-12-28T13:33:27","guid":{"rendered":"http:\/\/www.leadingtec.cn\/?p=2170"},"modified":"2016-05-06T15:19:01","modified_gmt":"2016-05-06T07:19:01","slug":"%e7%94%b2%e8%97%bb%e8%b0%83%e6%8e%a7","status":"publish","type":"post","link":"https:\/\/www.leadingtec.cn\/%e7%94%b2%e8%97%bb%e8%b0%83%e6%8e%a7.html","title":{"rendered":"\u7532\u85fb\u7ec6\u80de\u5468\u671f\u8c03\u63a7"},"content":{"rendered":"<p><span style=\"font-size: 12pt;\">\u76ee\u524d\u5bf9\u7532\u85fb\u8d64\u6f6e\u7684\u53d1\u751f\u8fc7\u7a0b\u5df2\u57fa\u672c\u6e05\u695a\uff0c\u4e00\u822c\u5206\u4e3a\u56db\u4e2a\u5178\u578b\u7684\u9636\u6bb5\uff1a\u5f00\u59cb\u3001\u53d1\u5c55\u3001\u7206\u53d1\u548c\u6d88\u4ea1\u3002\u7814\u7a76\u8868\u660e\uff0c\u9664\u5c11\u6570\u7532\u85fb\u8d64\u6f6e\u662f\u4ece\u4f11\u7720\u5b62\u5b50\u840c\u53d1\u800c\u6765\uff0c\u8bb8\u591a\u662f\u76f4\u63a5\u4ece\u5904\u4e8e\u6b21\u9002\u5b9c\u6761\u4ef6\u4e0b\u7684\u8425\u517b\u7ec6\u80de\u76f4\u63a5\u53d1\u5c55\u5f62\u6210\u79cd\u6e90\uff0c\u5b83\u4eec\u5728\u9002\u5b9c\u7684\u6761\u4ef6\u4e0b\u8fc5\u901f\u5206\u88c2\u589e\u6b96\u5e76\u5f62\u6210\u8d64\u6f6e\uff08Smayda T. J., 2000\uff09\u3002\u76ee\u524d\u5bf9\u8fd9\u4e00\u590d\u6742\u8fc7\u7a0b\u7684\u8c03\u63a7\u673a\u5236\u8fd8\u4e0d\u662f\u5f88\u6e05\u695a\u3002<!--more--><\/span><\/p>\n<p><span style=\"font-size: 12pt;\">\u7814\u7a76\u8868\u660e\uff0c\u7ec6\u80de\u7684\u589e\u6b96\u3001\u751f\u957f\u4e43\u81f3\u79cd\u7fa4\u7684\u589e\u957f\u901f\u7387\u5747\u53d7\u5230\u7ec6\u80de\u5468\u671f\u7684\u8c03\u63a7\uff0c\u800c\u7ec6\u80de\u5468\u671f\u8c03\u8282\u7684\u5931\u63a7\u5219\u4f1a\u5f15\u8d77\u7ec6\u80de\u5f02\u5e38\u589e\u6b96\u548c\u5feb\u901f\u751f\u957f\uff08Nurse P., 1994\uff09\u3002\u5728\u771f\u6838\u7ec6\u80de\u4e2d\uff0c\u7ec6\u80de\u5468\u671f\u901a\u5e38\u5206\u4e3aG1\uff0cS\uff0cG2\u548cM\u56db\u4e2a\u671f\uff08\u56fe1.4\uff09\uff0c\u7ec6\u80de\u5468\u671f\u65f6\u95f4\u957f\u77ed\u4e3b\u8981\u53d6\u51b3\u4e8eG1\u671f\uff0c\u800cS\u3001M\u548cG2\u4e09\u4e2a\u671f\u5219\u76f8\u5bf9\u6052\u5b9a\u3002\u5728\u5404\u7ec6\u80de\u5468\u671f\u5747\u5b58\u5728\u4e00\u5173\u952e\u68c0\u9a8c\u70b9\uff0c\u5982G1\/S\u68c0\u9a8c\u70b9\uff0cS\u671f\u68c0\u9a8c\u70b9\u3001G2\/M\u68c0\u9a8c\u70b9\u548c\u4e2d-\u540e\u671f\u68c0\u9a8c\u70b9\uff0c\u8fd9\u4e9b\u68c0\u9a8c\u70b9\u662f\u7ec6\u80de\u5468\u671f\u8c03\u63a7\u7684\u4e00\u79cd\u673a\u5236\uff0c\u786e\u4fdd\u5468\u671f\u6bcf\u4e00\u65f6\u76f8\u4e8b\u4ef6\u6709\u5e8f\u3001\u5168\u90e8\u5b8c\u6210\u5e76\u4e0e\u5916\u754c\u73af\u5883\u56e0\u7d20\u76f8\u8054\u7cfb\u3002\u5f53\u7ec6\u80de\u5904\u4e8e\u4e0d\u9002\u751f\u957f\u73af\u5883\u4e2d\uff0c\u5982\u53d7\u5230\u5149\u548c\u8425\u517b\u76d0\u9650\u5236\u65f6\uff0c\u7ec6\u80de\u6682\u65f6\u8131\u79bb\u7ec6\u80de\u5468\u671f\uff0c\u8fdb\u5165G0\u671f\uff0c\u6b64\u65f6\u7ec6\u80de\u505c\u6b62\u5206\u88c2\uff0c\u4f46\u5177\u5907\u4e00\u5b9a\u7684\u751f\u7269\u5b66\u529f\u80fd\uff0c\u5728\u9002\u5f53\u7684\u523a\u6fc0\u4e0b\u53ef\u91cd\u65b0\u8fdb\u5165\u7ec6\u80de\u5468\u671f\uff0c\u8fdb\u884c\u7ec6\u80de\u5206\u88c2\uff08\u7fdf\u4e2d\u548c\u7b49, 2006\uff09\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt;\">\u5c3d\u7ba1\u5728\u771f\u6838\u751f\u7269\u5404\u7269\u79cd\u95f4\u5b58\u5728\u4e00\u5b9a\u7684\u5dee\u5f02\uff0c\u4f46\u6700\u57fa\u672c\u7684\u8c03\u63a7\u673a\u5236\u662f\u76f8\u540c\u7684\uff0c\u90fd\u662f\u901a\u8fc7\u4f9d\u8d56\u7ec6\u80de\u5206\u88c2\u86cb\u767d\u7684\u86cb\u767d\u6fc0\u9176\uff08Cyclin-dependent kinases, CDKs\uff09\u4e0e\u76f8\u5e94\u7684\u7ec6\u80de\u5206\u88c2\u86cb\u767d\uff08Cyclin\uff09\u5f62\u6210\u590d\u5408\u4f53\u800c\u4fc3\u4f7f\u7ec6\u80de\u8fdb\u5165\u5e76\u5b8c\u6210\u7ec6\u80de\u5206\u88c2\u8fc7\u7a0b\u7684\uff08Nigg E. A., 1995\uff09\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u7ec6\u80de\u5468\u671f\u86cb\u767d\u4e2dCycD\u662f\u7ec6\u80de\u5468\u671f\u8fd0\u884c\u7684\u8d77\u59cb\u56e0\u5b50\uff0c\u540c\u65f6\u53c8\u662f\u751f\u957f\u56e0\u5b50\u611f\u53d7\u5668\uff0c\u63a7\u5236\u7ec6\u80deG1\u671f\u5411S\u671f\u8fc7\u6e21\u3002\u6709\u7814\u7a76\u8868\u660e\uff0c\u70df\u8349\u7ec6\u80de\u4e2dCycD2\u7684\u8fc7\u91cf\u8868\u8fbe\u53ef\u7279\u522b\u5730\u52a0\u901fG1\u671f\uff0c\u660e\u663e\u7f29\u77ed\u7ec6\u80de\u4eceG1\u671f\u8fdb\u5165\uff33\u671f\u7684\u65f6\u95f4\uff0c\u70df\u8349\u690d\u682a\u7684\u751f\u957f\u901f\u7387\u548c\u751f\u7269\u91cf\u7d2f\u79ef\u52a0\u901f\uff0c\u5f00\u82b1\u671f\u4e5f\u5927\u5927\u63d0\u524d\uff08Cockcroft C.E. et al., 2000\uff09\u3002\u5728\u80bf\u7624\u7ec6\u80de\u4e2dCycD\u7684\u8fc7\u91cf\u8868\u8fbe\u53ef\u6fc0\u6d3bCDK4\u548cCDK6\u7684\u6d3b\u6027\uff0c\u7f29\u77edG1\u671f\uff0c\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u964d\u4f4e\u7ec6\u80de\u589e\u6b96\u5bf9\u6709\u4e1d\u5206\u88c2\u539f\u7684\u4f9d\u8d56\uff0c\u9020\u6210\u7ec6\u80de\u5468\u671f\u8c03\u8282\u5931\u63a7\u548c\u7ec6\u80de\u7684\u5f02\u5e38\u589e\u6b96\uff0c\u5bfc\u81f4\u80bf\u7624\u7684\u53d1\u751f\uff08Motokura T. et al., 1991\uff09\u3002\u7532\u85fb\u8d64\u6f6e\u7684\u7206\u53d1\u6027\u589e\u6b96\u53ef\u80fd\u4e0e\u7ec6\u80de\u5185\u53c2\u4e0e\u7ec6\u80de\u5468\u671f\u8c03\u63a7\u86cb\u767d\u7684\u5f02\u5e38\u8868\u8fbe\u6709\u5173\uff0c\u4ece\u800c\u5f15\u8d77\u7ec6\u80de\u5468\u671f\u7d0a\u4e71\uff0c\u5bfc\u81f4\u7ec6\u80de\u5f02\u5e38\u589e\u6b96\u3002\u56e0\u800c\u5f00\u5c55\u8d64\u6f6e\u7532\u85fb\u7ec6\u80de\u5468\u671f\u8c03\u63a7\u86cb\u767d\u53ca\u8c03\u8282\u673a\u5236\u7814\u7a76\u53ef\u80fd\u6709\u52a9\u4e8e\u63ed\u793a\u7532\u85fb\u8d64\u6f6e\u7684\u7206\u53d1\u673a\u7406\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt;\">\u76ee\u524d\u4e00\u4e9b\u7ec6\u80de\u5468\u671f\u86cb\u767d\u548c\u7ec6\u80de\u5468\u671f\u86cb\u767d\u4f9d\u8d56\u6027\u6fc0\u9176\u5df2\u5728\u6709\u5bb3\u8d64\u6f6e\u751f\u7269\u4e2d\u88ab\u9646\u7eed\u53d1\u73b0\u3002Leveson et al.\uff081999\uff09\u5728Gymnodinium catenatum\u548cAmphidinium carterae\u4e2d\u53d1\u73b0\u4e86\u4e00\u79cd\u7c7b\u4f3c\u589e\u6b96\u7ec6\u80de\u6838\u6297\u539f\uff08Proliferating cell nuclear antigen, PCNA\uff09\u7684\u86cb\u767d\uff0c\u5b83\u5728\u7ec6\u80de\u5468\u671f\u7684S\u671f\u8fbe\u5230\u6700\u5927\u503c\uff0c\u53ef\u80fd\u8d77\u7740\u8c03\u8282\u7ec6\u80deDNA\u590d\u5236\u7684\u4f5c\u7528\u3002Lin\u7b49\uff082000\uff09\u5728\u8d64\u6f6e\u751f\u7269Aureococcus anophagefferens\u4e2d\u53d1\u73b0\u4e86\u4e00\u79cd\u7c7b\u4f3c\u7ec6\u80de\u5468\u671f\u86cb\u767dB\u7684\u86cb\u767d\u8d28\uff0c\u5b83\u8c03\u8282\u7ec6\u80de\u5468\u671f\u4eceG2\u671f\u5411M\u671f\u8f6c\u5316\u3002Barbier\u7b49\uff082000\uff09\u5728\u8d64\u6f6e\u751f\u7269K. brevis\u4e2d\u4e5f\u53d1\u73b0\u4e86\u7c7b\u4f3c\u7684\u86cb\u767d\u3002Van Dolah\u7b49\uff081995\uff09\u5728\u5188\u6bd4\u4e9a\u85fbGambierdiscus toxicus\u4e2d\u53d1\u73b0\u4e86\u7ec6\u80de\u5468\u671f\u4f9d\u8d56\u6027\u86cb\u767d\u6fc0\u9176-CDK2\uff0c\u8be5\u9176\u7684\u8868\u8fbe\u8d2f\u7a7f\u6574\u4e2a\u7ec6\u80de\u5468\u671f\uff0c\u4f46\u53ea\u662f\u5728\u6697\u5468\u671f\u7684\u540e\u671f\u8868\u73b0\u6d3b\u529b\u3002\u6b64\u5916\uff0c\u4e00\u4e9b\u771f\u6838\u7ec6\u80de\u5468\u671f\u8c03\u63a7\u56e0\u5b50\uff0c\u5982\u5468\u671f\u86cb\u767d\u4f9d\u8d56\u6027\u86cb\u767d\u6fc0\u9176\u548c\u76f8\u5173\u7684\u7ec4\u86cb\u767d\u6fc0\u9176\u6d3b\u6027\u4e5f\u5df2\u5728\u8d64\u6f6e\u751f\u7269\u4e2d\u68c0\u6d4b\u5230Chan K.L. et al., 2002; Lam C.M.C. et al., 2001\uff09\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt;\">\u8fd9\u4e9b\u7814\u7a76\u8868\u660e\uff0c\u7ec6\u80de\u5468\u671f\u86cb\u767d\u53ef\u80fd\u5728\u7ec6\u80de\u5468\u671f\u8c03\u8282\u53ca\u8d64\u6f6e\u7206\u53d1\u8fc7\u7a0b\u4e2d\u8d77\u7740\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u5b83\u4eec\u901a\u8fc7\u8c03\u8282\u7ec6\u80de\u5468\u671f\u8fdb\u7a0b\uff0c\u7279\u522b\u662fG1\u671f\u5411S\u671f\u7684\u8fdb\u7a0b\uff0c\u8fdb\u800c\u8c03\u63a7\u7ec6\u80de\u7684\u5206\u88c2\u3001\u589e\u6b96\u3002\u56e0\u800c\u901a\u8fc7\u7814\u7a76\u7532\u85fb\u8d64\u6f6e\u7206\u53d1\u8fc7\u7a0b\u4e2d\u7ec6\u80de\u5468\u671f\u8c03\u63a7\u57fa\u56e0\u548c\u86cb\u767d\u6c34\u5e73\u5bf9\u63ed\u793a\u8d64\u6f6e\u7206\u53d1\u7684\u5206\u5b50\u673a\u5236\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u76ee\u524d\u5bf9\u7532\u85fb\u8d64\u6f6e\u7684\u53d1\u751f\u8fc7\u7a0b\u5df2\u57fa\u672c\u6e05\u695a\uff0c\u4e00\u822c\u5206\u4e3a\u56db\u4e2a\u5178\u578b\u7684\u9636\u6bb5\uff1a\u5f00\u59cb\u3001\u53d1\u5c55\u3001\u7206\u53d1\u548c\u6d88\u4ea1\u3002\u7814\u7a76\u8868\u660e\uff0c\u9664\u5c11\u6570\u7532\u85fb\u8d64\u6f6e\u662f\u4ece\u4f11\u7720\u5b62\u5b50\u840c\u53d1\u800c\u6765\uff0c\u8bb8\u591a\u662f\u76f4\u63a5\u4ece\u5904\u4e8e\u6b21\u9002\u5b9c\u6761\u4ef6\u4e0b\u7684\u8425\u517b\u7ec6\u80de\u76f4\u63a5\u53d1\u5c55\u5f62\u6210\u79cd\u6e90\uff0c\u5b83\u4eec\u5728\u9002\u5b9c\u7684\u6761\u4ef6\u4e0b\u8fc5\u901f\u5206\u88c2\u589e\u6b96\u5e76\u5f62\u6210\u8d64\u6f6e\uff08Smayda T. J., 2000\uff09\u3002\u76ee\u524d\u5bf9\u8fd9\u4e00\u590d\u6742\u8fc7\u7a0b\u7684\u8c03\u63a7\u673a\u5236\u8fd8\u4e0d\u662f\u5f88\u6e05\u695a\u3002<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[12],"tags":[281],"class_list":["post-2170","post","type-post","status-publish","format-standard","hentry","category-technology","tag-281"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.leadingtec.cn\/wp-json\/wp\/v2\/posts\/2170"}],"collection":[{"href":"https:\/\/www.leadingtec.cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.leadingtec.cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.leadingtec.cn\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.leadingtec.cn\/wp-json\/wp\/v2\/comments?post=2170"}],"version-history":[{"count":0,"href":"https:\/\/www.leadingtec.cn\/wp-json\/wp\/v2\/posts\/2170\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.leadingtec.cn\/wp-json\/wp\/v2\/media?parent=2170"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.leadingtec.cn\/wp-json\/wp\/v2\/categories?post=2170"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.leadingtec.cn\/wp-json\/wp\/v2\/tags?post=2170"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}