{"id":4754,"date":"2017-02-23T10:09:44","date_gmt":"2017-02-23T02:09:44","guid":{"rendered":"http:\/\/www.leadingtec.cn\/?p=4754"},"modified":"2017-02-23T10:12:59","modified_gmt":"2017-02-23T02:12:59","slug":"chinese-academy-of-sciences-breakthroughs-by-science","status":"publish","type":"post","link":"https:\/\/www.leadingtec.cn\/chinese-academy-of-sciences-breakthroughs-by-science.html","title":{"rendered":"\u4e2d\u79d1\u9662\u591a\u9879\u6210\u679c\u5165\u90092016\u5e74\u5ea6\u4e2d\u56fd\u79d1\u5b66\u5341\u5927\u8fdb\u5c55"},"content":{"rendered":"<p><span style=\"font-size: 12pt;\">2\u670820\u65e5\uff0c\u79d1\u5b66\u6280\u672f\u90e8\u57fa\u7840\u7814\u7a76\u53f8\u4e0e\u9ad8\u6280\u672f\u7814\u7a76\u53d1\u5c55\u4e2d\u5fc3\u8054\u5408\u53ec\u5f00\u201c2016\u5e74\u5ea6\u4e2d\u56fd\u79d1\u5b66\u5341\u5927\u8fdb\u5c55\u89e3\u8bfb\u4f1a\u201d\uff0c\u53d1\u5e03\u4e862016\u5e74\u5ea6\u4e2d\u56fd\u79d1\u5b66\u5341\u5927\u8fdb\u5c55\u3002\u4e2d\u56fd\u79d1\u5b66\u9662\u76f8\u5173\u5355\u4f4d\u72ec\u7acb\u6216\u5408\u4f5c\u53d6\u5f97\u76847\u9879\u91cd\u5927\u79d1\u5b66\u6210\u679c\u5165\u9009\uff0c\u5305\u62ec\uff1a\u7814\u5236\u51fa\u5c06\u4e8c\u6c27\u5316\u78b3\u9ad8\u6548\u6e05\u6d01\u8f6c\u5316\u4e3a\u6db2\u4f53\u71c3\u6599\u7684\u65b0\u578b\u94b4\u57fa\u7535\u50ac\u5316\u5242\uff1b\u5f00\u521b\u7164\u5236\u70ef\u70c3\u65b0\u6377\u5f84\uff1b\u63ed\u793a\u6c34\u7a3b\u4ea7\u91cf\u6027\u72b6\u6742\u79cd\u4f18\u52bf\u7684\u5206\u5b50\u9057\u4f20\u673a\u5236\uff1b\u63d0\u51fa\u57fa\u4e8e\u80c6\u56fa\u9187\u4ee3\u8c22\u8c03\u63a7\u7684\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u65b0\u65b9\u6cd5\uff1b\u53d1\u73b0\u7cbe\u5b50RNA\u53ef\u4f5c\u4e3a\u8bb0\u5fc6\u8f7d\u4f53\u5c06\u83b7\u5f97\u6027\u6027\u72b6\u8de8\u4ee3\u9057\u4f20\uff1b\u6784\u5efa\u51fa\u4e16\u754c\u4e0a\u9996\u4e2a\u975e\u4eba\u7075\u957f\u7c7b\u81ea\u95ed\u75c7\u6a21\u578b\uff1b\u63ed\u793a\u80da\u80ce\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u5173\u952e\u4fe1\u53f7\u901a\u8def\u7684\u8868\u89c2\u9057\u4f20\u8c03\u63a7\u673a\u7406\u3002<\/span><\/p>\n<figure id=\"attachment_4755\" aria-describedby=\"caption-attachment-4755\" style=\"width: 400px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.leadingtec.cn\/wp-content\/uploads\/2017\/02\/W020170221383035979744.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-4755\" src=\"https:\/\/www.leadingtec.cn\/wp-content\/uploads\/2017\/02\/W020170221383035979744.jpg\" alt=\"\u4e2d\u79d1\u9662\u591a\u9879\u6210\u679c\u5165\u90092016\u5e74\u5ea6\u4e2d\u56fd\u79d1\u5b66\u5341\u5927\u8fdb\u5c55\" width=\"400\" height=\"319\" srcset=\"https:\/\/www.leadingtec.cn\/wp-content\/uploads\/2017\/02\/W020170221383035979744.jpg 400w, https:\/\/www.leadingtec.cn\/wp-content\/uploads\/2017\/02\/W020170221383035979744-300x239.jpg 300w\" sizes=\"(max-width: 400px) 100vw, 400px\" \/><\/a><figcaption id=\"caption-attachment-4755\" class=\"wp-caption-text\">\u4e2d\u79d1\u9662\u591a\u9879\u6210\u679c\u5165\u90092016\u5e74\u5ea6\u4e2d\u56fd\u79d1\u5b66\u5341\u5927\u8fdb\u5c55<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12pt;\">\u5176\u4ed63\u9879\u5165\u9009\u6210\u679c\u4e3a\uff1a\u63ed\u793aRNA\u526a\u63a5\u7684\u5173\u952e\u5206\u5b50\u673a\u5236\uff1b\u7814\u5236\u51fa\u9996\u4e2a\u7a33\u5b9a\u53ef\u63a7\u7684\u5355\u5206\u5b50\u7535\u5b50\u5f00\u5173\u5668\u4ef6\uff1b\u63ed\u793a\u6c34\u7684\u6838\u91cf\u5b50\u6548\u5e94\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12pt;\">\u4e2d\u56fd\u79d1\u5b66\u5341\u5927\u8fdb\u5c55\u9074\u9009\u6d3b\u52a8\u7531\u79d1\u6280\u90e8\u9ad8\u6280\u672f\u7814\u7a76\u53d1\u5c55\u4e2d\u5fc3\u4e3b\u529e\uff0c\u81f3\u4eca\u5df2\u6210\u529f\u4e3e\u529e12\u5c4a\uff0c\u65e8\u5728\u5ba3\u4f20\u6211\u56fd\u91cd\u5927\u57fa\u7840\u7814\u7a76\u79d1\u5b66\u8fdb\u5c55\uff0c\u6fc0\u52b1\u5e7f\u5927\u79d1\u6280\u5de5\u4f5c\u8005\u7684\u79d1\u5b66\u70ed\u60c5\u548c\u5949\u732e\u7cbe\u795e\uff0c\u5f00\u5c55\u57fa\u7840\u7814\u7a76\u79d1\u666e\u5ba3\u4f20\uff0c\u4fc3\u8fdb\u516c\u4f17\u7406\u89e3\u3001\u5173\u5fc3\u548c\u652f\u6301\u79d1\u5b66\u57fa\u7840\u7814\u7a76\uff0c\u5728\u5168\u793e\u4f1a\u8425\u9020\u826f\u597d\u7684\u79d1\u5b66\u6c1b\u56f4\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12pt;\">\u4e2d\u56fd\u79d1\u5b66\u5341\u5927\u8fdb\u5c55\u9074\u9009\u7a0b\u5e8f\u5206\u4e3a\u63a8\u8350\u3001\u521d\u9009\u548c\u7ec8\u90093\u4e2a\u73af\u8282\u3002\u300a\u4e2d\u56fd\u57fa\u7840\u79d1\u5b66\u300b\u3001\u300a\u79d1\u6280\u5bfc\u62a5\u300b\u3001\u300a\u4e2d\u56fd\u79d1\u5b66\u9662\u9662\u520a\u300b\u3001\u300a\u4e2d\u56fd\u79d1\u5b66\u57fa\u91d1\u300b\u548c\u300a\u79d1\u5b66\u901a\u62a5\u300b5\u5bb6\u7f16\u8f91\u90e8\u63a8\u8350\u4e862015\u5e7412\u67081\u65e5\u81f32016\u5e7411\u670830\u65e5\u671f\u95f4\u6b63\u5f0f\u53d1\u8868\u7684\u79d1\u5b66\u7814\u7a76\u6210\u679c\u5171278\u9879\u30022016\u5e741\u6708\uff0c\u79d1\u6280\u90e8\u9ad8\u6280\u672f\u7814\u7a76\u53d1\u5c55\u4e2d\u5fc3\u7ec4\u7ec7\u53ec\u5f00\u521d\u9009\u4f1a\u8bae\uff0c\u9080\u8bf7\u4e13\u5bb6\u4ece\u63a8\u8350\u7684\u79d1\u5b66\u8fdb\u5c55\u4e2d\u9074\u9009\u51fa30\u9879\u8fdb\u5165\u7ec8\u9009\u3002\u7ec8\u9009\u91c7\u53d6\u7f51\u4e0a\u6295\u7968\u65b9\u5f0f\uff0c\u9080\u8bf7\u4e24\u9662\u9662\u58eb\u3001973\u8ba1\u5212\u987e\u95ee\u7ec4\u548c\u54a8\u8be2\u7ec4\u4e13\u5bb6\u3001973\u8ba1\u5212\u9879\u76ee\u9996\u5e2d\u79d1\u5b66\u5bb6\u3001\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4\u4e3b\u4efb\u7b492000\u4f59\u540d\u4e13\u5bb6\u5b66\u8005\u5bf9\u5019\u9009\u79d1\u5b66\u8fdb\u5c55\u8fdb\u884c\u7f51\u4e0a\u6295\u7968\uff0c\u5f97\u7968\u6570\u6392\u540d\u524d10\u4f4d\u7684\u6210\u4e3a2016\u5e74\u5ea6\u4e2d\u56fd\u79d1\u5b66\u5341\u5927\u8fdb\u5c55\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12pt;\"><strong>\u9644\uff1a2016\u5e74\u5ea6\u4e2d\u56fd\u79d1\u5b66\u5341\u5927\u8fdb\u5c55\u8fdb\u5c55\u7b80\u4ecb<\/strong><\/span><\/p>\n<p><span style=\"font-size: 12pt;\"><strong>\u3000\u3000<\/strong><\/span><\/p>\n<p><span style=\"font-size: 12pt;\"><strong>1. \u7814\u5236\u51fa\u5c06\u4e8c\u6c27\u5316\u78b3\u9ad8\u6548\u6e05\u6d01\u8f6c\u5316\u4e3a\u6db2\u4f53\u71c3\u6599\u7684\u65b0\u578b\u94b4\u57fa\u7535\u50ac\u5316\u5242<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12pt;\">\u5c06\u4e8c\u6c27\u5316\u78b3\u5728\u5e38\u6e29\u5e38\u538b\u4e0b\u7535\u8fd8\u539f\u4e3a\u78b3\u6c22\u71c3\u6599\uff0c\u662f\u4e00\u79cd\u6f5c\u5728\u7684\u66ff\u4ee3\u5316\u77f3\u539f\u6599\u7684\u6e05\u6d01\u80fd\u6e90\u7b56\u7565\uff0c\u5e76\u6709\u52a9\u4e8e\u964d\u4f4e\u4e8c\u6c27\u5316\u78b3\u6392\u653e\u5bf9\u6c14\u5019\u9020\u6210\u7684\u4e0d\u5229\u5f71\u54cd\u3002\u5b9e\u73b0\u4e8c\u6c27\u5316\u78b3\u7535\u50ac\u5316\u8fd8\u539f\u7684\u5173\u952e\u74f6\u9888\u95ee\u9898\u662f\u5c06\u4e8c\u6c27\u5316\u78b3\u6d3b\u5316\u4e3aCO2\u2022\u2212\u81ea\u7531\u57fa\u8d1f\u79bb\u5b50\u6216\u5176\u5b83\u4e2d\u95f4\u4f53\uff0c\u8fd9\u9700\u8981\u5f02\u5e38\u9ad8\u7684\u8fc7\u7535\u4f4d\u3002\u6700\u8fd1\u62a5\u9053\u663e\u793a\uff0c\u57fa\u4e8e\u91d1\u5c5e\u6c27\u5316\u7269\u8fd8\u539f\u5f97\u5230\u7684\u91d1\u5c5e\u6bd4\u901a\u8fc7\u5176\u5b83\u65b9\u6cd5\u5236\u5907\u7684\u91d1\u5c5e\u50ac\u5316\u6d3b\u6027\u8981\u9ad8\uff0c\u4f46\u662f\u4e0d\u6e05\u695a\u91d1\u5c5e\u6c27\u5316\u7269\u5982\u4f55\u6539\u53d8\u4e86\u91d1\u5c5e\u7684\u7535\u50ac\u5316\u6d3b\u6027\uff0c\u8fd9\u4e3b\u8981\u662f\u56e0\u4e3a\u754c\u9762\u548c\u7f3a\u9677\u7b49\u5fae\u7ed3\u6784\u7684\u5b58\u5728\u5f71\u54cd\u4e86\u4e8c\u6c27\u5316\u78b3\u8fd8\u539f\u7684\u6d3b\u6027\u3002\u4e3a\u4e86\u8bc4\u4f30\u91d1\u5c5e\u548c\u91d1\u5c5e\u6c27\u5316\u7269\u4e24\u79cd\u4e0d\u540c\u50ac\u5316\u4f4d\u70b9\u7684\u4f5c\u7528\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u9662\u58eb\u3001\u4e2d\u56fd\u79d1\u5b66\u6280\u672f\u5927\u5b66\u6559\u6388\u8c22\u6bc5\u548c\u5b59\u6c38\u798f\u7814\u7a76\u7ec4\u5236\u5907\u4e86\u56db\u539f\u5b50\u539a\u7684\u94b4\u91d1\u5c5e\u5c42\u548c\u94b4\u91d1\u5c5e\/\u6c27\u5316\u94b4\u6742\u5316\u5c42\u3002\u4ed6\u4eec\u53d1\u73b0\u5728\u4f4e\u8fc7\u7535\u4f4d\u4e0b\uff0c\u76f8\u5bf9\u4e8e\u5757\u6750\u8868\u9762\u7684\u94b4\u539f\u5b50\uff0c\u539f\u5b50\u7ea7\u8584\u5c42\u8868\u9762\u7684\u94b4\u539f\u5b50\u5177\u6709\u66f4\u9ad8\u7684\u751f\u6210\u7532\u9178\u76d0\u7684\u672c\u5f81\u6d3b\u6027\u548c\u9009\u62e9\u6027\u3002\u800c\u90e8\u5206\u6c27\u5316\u7684\u539f\u5b50\u5c42\u8fdb\u4e00\u6b65\u63d0\u9ad8\u4e86\u5b83\u4eec\u7684\u672c\u5f81\u50ac\u5316\u6d3b\u6027\uff0c\u5728\u8fc7\u7535\u4f4d\u4ec5\u4e3a0.24\u4f0f\u4e0b\u5b9e\u73b0\u4e8610\u6beb\u5b89\u6bcf\u5e73\u65b9\u5398\u7c73\u7684\u7535\u6d41\u8f93\u51fa\u8d85\u8fc740\u5c0f\u65f6\uff0c\u4e14\u5176\u7532\u9178\u76d0\u9009\u62e9\u6027\u63a5\u8fd190%\uff0c\u8fd9\u8d85\u8fc7\u6b64\u524d\u62a5\u9053\u7684\u91d1\u5c5e\u6216\u91d1\u5c5e\u6c27\u5316\u7269\u7535\u6781\u5728\u540c\u7b49\u6761\u4ef6\u4e0b\u5f97\u5230\u7684\u7ed3\u679c\u3002\u8be5\u7814\u7a76\u5de5\u4f5c\u6709\u52a9\u4e8e\u8ba9\u7814\u7a76\u8005\u91cd\u65b0\u601d\u8003\u5982\u4f55\u83b7\u5f97\u9ad8\u6548\u548c\u7a33\u5b9a\u7684CO2\u7535\u8fd8\u539f\u50ac\u5316\u5242\u3002\u76f8\u5173\u7814\u7a76\u8bba\u6587\u53d1\u8868\u57282016\u5e741\u67087\u65e5\u300a\u81ea\u7136\u300b(<em>Nature<\/em> [529(7584):68\u201471])\u4e0a\u3002\u52a0\u5dde\u7406\u5de5\u5927\u5b66\u6559\u6388Karthish Manthiram\u8bc4\u8bba\u8ba4\u4e3a\uff0c\u201c\u8fd9\u662f\u4e00\u6b21\u91cd\u5927\u7684\u79d1\u5b66\u7a81\u7834\u3002\u867d\u7136\u5b83\u5728\u8fdb\u5165\u5546\u4e1a\u5316\u4f7f\u7528\u4e4b\u524d\u8fd8\u9700\u8981\u4e00\u6bb5\u975e\u5e38\u957f\u7684\u65f6\u95f4\uff0c\u4f46\u662f\u76ee\u524d\u8fd9\u4e2a\u9636\u6bb5\u7684\u53d1\u5c55\u4e0d\u7ba1\u4ece\u54ea\u4e2a\u89d2\u5ea6\u770b\u90fd\u662f\u79ef\u6781\u4e50\u89c2\u7684\u3002\u201d<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12pt;\"><strong>2. \u5f00\u521b\u7164\u5236\u70ef\u70c3\u65b0\u6377\u5f84<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12pt;\">\u70ef\u70c3\u662f\u4e0e\u4eba\u4eec\u65e5\u5e38\u751f\u6d3b\u606f\u606f\u76f8\u5173\u7684\u91cd\u8981\u5316\u5b66\u54c1\u3002\u6211\u56fd\u662f\u70ef\u70c3\u6d88\u8d39\u5927\u56fd\uff0c\u5176\u4f20\u7edf\u7684\u751f\u4ea7\u539f\u6599\u4e3b\u8981\u4f9d\u8d56\u77f3\u6cb9\uff0c\u8fd9\u4e0d\u4ec5\u4f7f\u70ef\u70c3\u7684\u751f\u4ea7\u6210\u672c\u5c45\u9ad8\u4e0d\u4e0b\uff0c\u540c\u65f6\u4e5f\u4e25\u91cd\u5730\u5371\u53ca\u5230\u4e86\u6211\u56fd\u7684\u80fd\u6e90\u5b89\u5168\u300220\u4e16\u7eaa\u521d\uff0c\u5fb7\u56fd\u79d1\u5b66\u5bb6\u8d39\u820d\u5c14\u548c\u62d3\u666e\u5e0c\u63d0\u51fa\u4e86\u4e00\u6761\u7531\u7164\u7ecf\u6c34\u7164\u6c14\u53d8\u6362\u751f\u4ea7\u70ef\u70c3\u7684\u8d39-\u6258(F-T)\u8def\u7ebf\uff0c\u4f46\u662f\uff0c\u8be5\u8fc7\u7a0b\u539f\u7406\u4e0a\u4f1a\u4ea7\u751f\u5927\u91cf\u7684\u526f\u4ea7\u7269\uff0c\u540c\u65f6\u8fd8\u9700\u8981\u6d88\u8017\u5927\u91cf\u7684\u6c34\uff0c\u4e25\u91cd\u963b\u788d\u4e86\u8be5\u6280\u672f\u53d1\u5c55\u548c\u5b9e\u9645\u5e94\u7528\u3002\u4e2d\u56fd\u79d1\u5b66\u9662\u9662\u58eb\u3001\u4e2d\u56fd\u79d1\u5b66\u9662\u5927\u8fde\u5316\u5b66\u7269\u7406\u7814\u7a76\u6240\u7814\u7a76\u5458\u5305\u4fe1\u548c\u53ca\u6f58\u79c0\u83b2\u7814\u7a76\u56e2\u961f\u4ece\u7eb3\u7c73\u50ac\u5316\u7684\u57fa\u672c\u539f\u7406\u5165\u624b\uff0c\u5f00\u53d1\u51fa\u4e86\u4e00\u79cd\u8fc7\u6e21\u91d1\u5c5e\u6c27\u5316\u7269\u548c\u6709\u5e8f\u5b54\u9053\u5206\u5b50\u7b5b\u590d\u5408\u50ac\u5316\u5242\uff0c\u6210\u529f\u5b9e\u73b0\u4e86\u7164\u57fa\u5408\u6210\u6c14\u4e00\u6b65\u6cd5\u9ad8\u6548\u751f\u4ea7\u70ef\u70c3\uff0cC2\u5230C4\u4f4e\u78b3\u70ef\u70c3\u5355\u7a0b\u9009\u62e9\u6027\u7a81\u7834\u4e86\u8d39\u6258\u8fc7\u7a0b\u7684\u6781\u9650\uff0c\u4e00\u8dc3\u8d85\u8fc780%\u3002\u540c\u65f6\uff0c\u53cd\u5e94\u8fc7\u7a0b\u5b8c\u5168\u907f\u514d\u4e86\u6c34\u5206\u5b50\u7684\u53c2\u4e0e\uff0c\u4ece\u6e90\u5934\u56de\u7b54\u4e86\u674e\u514b\u5f3a\u603b\u7406\u63d0\u51fa\u7684\u201c\u80fd\u4e0d\u80fd\u4e0d\u7528\u6c34\u6216\u8005\u5c11\u7528\u6c34\u8fdb\u884c\u7164\u5316\u5de5\u201d\u7684\u8bd8\u95ee\u3002\u8be5\u6210\u679c\u5728\u7eb3\u7c73\u5c3a\u5ea6\u4e0a\u5b9e\u73b0\u4e86\u5bf9\u5206\u522b\u63a7\u5236\u53cd\u5e94\u6d3b\u6027\u548c\u4ea7\u7269\u9009\u62e9\u6027\u7684\u4e24\u7c7b\u50ac\u5316\u6d3b\u6027\u4e2d\u5fc3\u7684\u6709\u6548\u5206\u79bb\uff0c\u4f7f\u5728\u6c27\u5316\u7269\u50ac\u5316\u5242\u8868\u9762\u751f\u6210\u7684\u78b3\u6c22\u4e2d\u95f4\u4f53\u5728\u5206\u5b50\u7b5b\u7684\u7eb3\u7c73\u5b54\u9053\u4e2d\u53d1\u751f\u53d7\u9650\u5076\u8054\u53cd\u5e94\uff0c\u6210\u529f\u5b9e\u73b0\u4e86\u76ee\u6807\u4ea7\u7269\u968f\u5206\u5b50\u7b5b\u7ed3\u6784\u7684\u53ef\u63a7\u8c03\u53d8\u3002\u76f8\u5173\u7814\u7a76\u8bba\u6587\u53d1\u8868\u57282016\u5e743\u67084\u65e5\u300a\u79d1\u5b66\u300b(<em>Science<\/em> [351(6277):1065\u20141068])\u4e0a\u3002\u300a\u79d1\u5b66\u300b\u540c\u671f\u4ee5\u201c\u4ee4\u4eba\u60ca\u5947\u7684\u9009\u62e9\u6027\u201d\u4e3a\u9898\u520a\u53d1\u4e86\u4e13\u5bb6\u8bc4\u8bba\u548c\u5c55\u671b\uff0c\u79f0\u8d5e\u8be5\u7814\u7a76\u5728\u539f\u7406\u4e0a\u7684\u7a81\u7834\u5c06\u5e26\u6765\u5728\u5de5\u4e1a\u4e0a\u7684\u5de8\u5927\u7ade\u4e89\u529b\u3002\u8be5\u7814\u7a76\u5e76\u88ab\u4ea7\u4e1a\u754c\u540c\u884c\u8a89\u4e3a\u201c\u7164\u8f6c\u5316\u9886\u57df\u91cc\u7a0b\u7891\u5f0f\u7684\u91cd\u5927\u7a81\u7834\u201d\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12pt;\"><strong>3. \u63ed\u793a\u6c34\u7a3b\u4ea7\u91cf\u6027\u72b6\u6742\u79cd\u4f18\u52bf\u7684\u5206\u5b50\u9057\u4f20\u673a\u5236<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12pt;\">\u4e0d\u65ad\u63d0\u9ad8\u8c37\u7269\u4ea7\u91cf\u4ee5\u4fdd\u969c\u5168\u7403\u7cae\u98df\u5b89\u5168\u662f\u4f5c\u7269\u9057\u4f20\u80b2\u79cd\u7684\u957f\u671f\u76ee\u6807\u3002\u6742\u79cd\u4f18\u52bf\u662f\u6307\u901a\u8fc7\u6742\u4ea4\u4f7f\u540e\u4ee3\u5c55\u73b0\u51fa\u6bd4\u7236\u672c\u548c\u6bcd\u672c\u5177\u6709\u66f4\u4f18\u52bf\u6027\u72b6\u7684\u73b0\u8c61\uff0c\u662f\u4e00\u79cd\u91cd\u8981\u7684\u4f5c\u7269\u80b2\u79cd\u7b56\u7565\u3002\u4e3a\u4e86\u63ed\u793a\u6c34\u7a3b\u4ea7\u91cf\u6027\u72b6\u6742\u79cd\u4f18\u52bf\u7684\u9057\u4f20\u57fa\u7840\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u9662\u58eb\u3001\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u751f\u547d\u79d1\u5b66\u7814\u7a76\u9662\u690d\u7269\u751f\u7406\u751f\u6001\u7814\u7a76\u6240\u7814\u7a76\u5458\u97e9\u658c\u548c\u9ec4\u5b66\u8f89\u7814\u7a76\u7ec4\u4e0e\u4e2d\u56fd\u6c34\u7a3b\u6240\u7814\u7a76\u5458\u6768\u4ed5\u534e\u5408\u4f5c\uff0c\u5bf917\u5957\u4ee3\u8868\u6027\u6742\u4ea4\u6c34\u7a3b\u54c1\u7cfb\u768410074\u4efdF2\u4ee3\u6750\u6599\u8fdb\u884c\u4e86\u57fa\u56e0\u578b\u548c\u8868\u578b\u6027\u72b6\u5206\u6790\u3002\u4ed6\u4eec\u56e0\u6b64\u7cfb\u7edf\u9274\u5b9a\u4e86\u4e0e\u6c34\u7a3b\u4ea7\u91cf\u6742\u79cd\u4f18\u52bf\u76f8\u5173\u7684\u9057\u4f20\u4f4d\u70b9\uff0c\u5e76\u5c06\u73b0\u4ee3\u6742\u4ea4\u6c34\u7a3b\u54c1\u7cfb\u9274\u5b9a\u4e3a3\u4e2a\u7fa4\u7cfb\uff0c\u4ee3\u8868\u4e86\u4e0d\u540c\u7684\u6742\u4ea4\u80b2\u79cd\u4f53\u7cfb\u3002\u4ed6\u4eec\u53d1\u73b0\uff0c\u867d\u7136\u5728\u6240\u6709\u6742\u4ea4\u7a3b\u4e2d\u5e76\u6ca1\u6709\u5b8c\u5168\u76f8\u540c\u7684\u4e0e\u6742\u79cd\u4f18\u52bf\u76f8\u5173\u7684\u9057\u4f20\u4f4d\u70b9\uff0c\u4f46\u5728\u540c\u4e00\u7fa4\u7cfb\u5185\uff0c\u90fd\u6709\u5c11\u91cf\u6765\u81ea\u6bcd\u672c\u7684\u57fa\u56e0\u4f4d\u70b9\u901a\u8fc7\u4e0d\u5b8c\u5168\u663e\u6027\u7684\u673a\u5236\u5bf9\u5927\u90e8\u5206\u6742\u79cd\u7684\u4ea7\u91cf\u4f18\u52bf\u6709\u91cd\u8981\u8d21\u732e\u3002\u8fd9\u4e00\u53d1\u73b0\u5c06\u6709\u5229\u4e8e\u8fdb\u884c\u9ad8\u6548\u7684\u6742\u4ea4\u4f18\u5316\u914d\u7ec4\uff0c\u4ee5\u5feb\u901f\u83b7\u5f97\u5177\u6709\u9ad8\u4ea7\u3001\u4f18\u8d28\u548c\u6297\u9006\u7684\u6742\u4ea4\u54c1\u79cd\u3002\u76f8\u5173\u7814\u7a76\u8bba\u6587\u4ee5\u957f\u6587\u5f62\u5f0f\u53d1\u8868\u57282016\u5e749\u670829\u65e5\u300a\u81ea\u7136\u300b(<em>Nature<\/em> [537(7622): 629\u2014633])\u4e0a\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12pt;\"><strong>4. \u63d0\u51fa\u57fa\u4e8e\u80c6\u56fa\u9187\u4ee3\u8c22\u8c03\u63a7\u7684\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u65b0\u65b9\u6cd5<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12pt;\">T\u7ec6\u80de\u4ecb\u5bfc\u7684\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u662f\u6cbb\u7597\u80bf\u7624\u6700\u6709\u6548\u7684\u56db\u79cd\u6b66\u5668\u4e4b\u4e00\uff0c\u5728\u4e34\u5e8a\u4e0a\u5df2\u53d6\u5f97\u4e86\u5de8\u5927\u7684\u6210\u529f\u3002\u4f46\u73b0\u6709\u7684\u57fa\u4e8e\u4fe1\u53f7\u8f6c\u5bfc\u8c03\u63a7\u7684\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u624b\u6bb5\u53ea\u5bf9\u90e8\u5206\u75c5\u4eba\u6709\u6548\uff0c\u56e0\u6b64\u6025\u9700\u53d1\u5c55\u65b0\u7684\u65b9\u6cd5\u8ba9\u66f4\u591a\u7684\u75c5\u4eba\u53d7\u76ca\u3002\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u751f\u547d\u79d1\u5b66\u7814\u7a76\u9662\u751f\u7269\u5316\u5b66\u4e0e\u7ec6\u80de\u751f\u7269\u5b66\u7814\u7a76\u6240\u7814\u7a76\u5458\u8bb8\u741b\u7426\u3001\u674e\u4f2f\u826f\u4e0e\u5408\u4f5c\u8005\u4ece\u5168\u65b0\u89d2\u5ea6\u7814\u7a76\u4e86T\u7ec6\u80de\u7684\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u53cd\u5e94\u3002\u4ed6\u4eec\u8ba4\u4e3a\u901a\u8fc7\u8c03\u63a7T\u7ec6\u80de\u7684\u201c\u4ee3\u8c22\u68c0\u67e5\u70b9\u201d\u53ef\u6539\u53d8\u5176\u4ee3\u8c22\u72b6\u6001\uff0c\u4f7f\u5176\u83b7\u5f97\u66f4\u5f3a\u7684\u6297\u80bf\u7624\u6548\u5e94\u529f\u80fd\u3002\u4ed6\u4eec\u9274\u5b9a\u51fa\u80c6\u56fa\u9187\u916f\u5316\u9176ACAT1\u662f\u8c03\u63a7\u80bf\u7624\u514d\u75ab\u5e94\u7b54\u7684\u4ee3\u8c22\u68c0\u67e5\u70b9\uff0c\u6291\u5236\u5176\u6d3b\u6027\u53ef\u4ee5\u589e\u5f3aCD8+ T\u7ec6\u80de\u7684\u80bf\u7624\u6740\u4f24\u80fd\u529b\u3002\u5176\u4e3b\u8981\u673a\u7406\u662fCD8+ T\u7ec6\u80de\u8d28\u819c\u80c6\u56fa\u9187\u6c34\u5e73\u660e\u663e\u589e\u52a0\uff0c\u5e2e\u52a9T\u7ec6\u80de\u6297\u539f\u53d7\u4f53\u7c07\u548c\u514d\u75ab\u7a81\u89e6\u9ad8\u6548\u5f62\u6210\u3002\u4ed6\u4eec\u8fd8\u53d1\u73b0ACAT1\u6291\u5236\u5242Avasimibe(\u4f5c\u4e3a\u7528\u4e8e\u6cbb\u7597\u52a8\u8109\u7ca5\u6837\u786c\u5316\u76f8\u5173\u75be\u75c5\u7684\u836f\u7269\uff0c\u5df2\u8fdb\u884c\u4e86III\u671f\u4e34\u5e8a\u8bd5\u9a8c)\u5177\u6709\u5f88\u597d\u7684\u6297\u80bf\u7624\u6548\u5e94\uff0c\u5e76\u4e14\u80fd\u4e0e\u73b0\u6709\u7684\u4e34\u5e8a\u836f\u7269PD-1\u6297\u4f53\u8054\u5408\u6cbb\u7597\u6765\u83b7\u5f97\u66f4\u597d\u7684\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u6548\u679c\u3002\u4ed6\u4eec\u7684\u7814\u7a76\u5f00\u8f9f\u4e86\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u7684\u4e00\u4e2a\u5168\u65b0\u9886\u57df\uff0c\u8bc1\u660e\u4e86\u4ee3\u8c22\u8c03\u63a7\u7684\u5173\u952e\u4f5c\u7528\uff1b\u540c\u65f6\u53d1\u73b0ACAT1\u8fd9\u4e00\u65b0\u7684\u6cbb\u7597\u9776\u70b9\uff0c\u62d3\u5c55\u4e86ACAT1\u5c0f\u5206\u5b50\u6291\u5236\u5242\u7684\u5e94\u7528\u524d\u666f\uff0c\u4e3a\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u601d\u8def\u4e0e\u65b0\u65b9\u6cd5\u3002\u76f8\u5173\u7814\u7a76\u8bba\u6587\u53d1\u8868\u57282016\u5e743\u670831\u65e5\u300a\u81ea\u7136\u300b(<em>Nature<\/em> [531(7596):651\u2014655])\u4e0a\u3002\u300a\u81ea\u7136\u300b\u53d1\u8868\u7684\u540c\u884c\u8bc4\u8bba\u6307\u51fa\uff1a\u201c\u8fd9\u9879\u7814\u7a76\u6210\u679c\u53ef\u80fd\u5f00\u53d1\u6210\u6297\u80bf\u7624\u548c\u6297\u75c5\u6bd2\u7684\u65b0\u836f\u7269\u3002\u201d\u300a\u7ec6\u80de\u300b\u53d1\u8868\u7684\u540c\u884c\u8bc4\u8bba\u6307\u51fa\uff1a\u201c\u8fd9\u9879\u7814\u7a76\u4e3a\u5bf9anti-PD-1\u6ca1\u6709\u6cbb\u7597\u6548\u5e94\u6216\u4ea7\u751f\u62b5\u6297\u7684\u75c5\u4eba\u63d0\u4f9b\u4e86\u65b0\u7684\u5e0c\u671b\u3002\u201d<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12pt;\"><strong>5. \u63ed\u793aRNA\u526a\u63a5\u7684\u5173\u952e\u5206\u5b50\u673a\u5236<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12pt;\">RNA\u526a\u63a5\u662f\u5730\u7403\u4e0a\u6240\u6709\u771f\u6838\u751f\u7269\u4eceDNA\u5230\u86cb\u767d\u8d28\u4fe1\u606f\u4f20\u9012\u8fd9\u4e00\u201c\u4e2d\u5fc3\u6cd5\u5219\u201d\u7684\u5173\u952e\u4e00\u73af\u3002\u901a\u8fc7\u526a\u63a5\u53cd\u5e94\uff0c\u524d\u4f53\u4fe1\u4f7fRNA\u4e2d\u7684\u5185\u542b\u5b50\u88ab\u5254\u9664\u3001\u5916\u663e\u5b50\u8fde\u63a5\u8d77\u6765\u5f62\u6210\u6210\u719f\u7684\u4fe1\u4f7fRNA\uff0c\u8fdb\u4e00\u6b65\u624d\u80fd\u88ab\u7ffb\u8bd1\u6210\u86cb\u767d\u8d28\u3002\u4eba\u7c7b\u5df2\u77e5\u7684\u9057\u4f20\u75be\u75c5\u4e2d\u5927\u7ea635%\u662f\u7531RNA\u526a\u63a5\u7684\u5f02\u5e38\u5bfc\u81f4\u7684\u3002RNA\u526a\u63a5\u7684\u5316\u5b66\u672c\u8d28\u662f\u524d\u4f53\u4fe1\u4f7fRNA\u7ecf\u5386\u4e24\u6b65\u8f6c\u916f\u53cd\u5e94\u5b8c\u6210\u526a\u548c\u63a5\u4e24\u4e2a\u5173\u952e\u6b65\u9aa4\uff0c\u6bcf\u4e00\u6b65\u90fd\u9700\u8981\u7531\u4e00\u4e2a\u5de8\u5927\u7684\u52a8\u6001\u5206\u5b50\u673a\u5668\u2014\u2014\u526a\u63a5\u4f53\u6765\u50ac\u5316\u5b8c\u6210\u3002\u56e0\u6b64\uff0c\u83b7\u53d6\u5206\u5b50\u91cf\u8fbe\u4e24\u767e\u4e07\u9053\u5c14\u987f\u4ee5\u4e0a\u7684\u526a\u63a5\u4f53\u5728\u7ec4\u88c5\u3001\u6fc0\u6d3b\u3001\u50ac\u5316\u53cd\u5e94\u8fc7\u7a0b\u4e2d\u5404\u4e2a\u72b6\u6001\u7684\u9ad8\u5206\u8fa8\u7387\u7a7a\u95f4\u4e09\u7ef4\u7ed3\u6784\u662f\u7406\u89e3RNA\u526a\u63a5\u5206\u5b50\u673a\u5236\u7684\u5fc5\u7ecf\u4e4b\u8def\uff0c\u4e5f\u662f\u7ed3\u6784\u751f\u7269\u5b66\u754c\u6700\u5bcc\u6311\u6218\u6027\u7684\u8bfe\u9898\u3002\u8fc7\u53bb30\u5e74\uff0c\u8fd9\u4e00\u751f\u547d\u79d1\u5b66\u57fa\u7840\u7814\u7a76\u7684\u6838\u5fc3\u9886\u57df\u8fdb\u5c55\u7f13\u6162\u3002\u4e2d\u56fd\u79d1\u5b66\u9662\u9662\u58eb\u3001\u6e05\u534e\u5927\u5b66\u751f\u547d\u79d1\u5b66\u5b66\u9662\u6559\u6388\u65bd\u4e00\u516c\u5b9e\u9a8c\u5ba4\u9488\u5bf9\u8fd9\u4e00\u91cd\u5927\u79d1\u5b66\u96be\u9898\uff0c\u521b\u65b0\u6027\u5730\u5229\u7528\u9175\u6bcd\u5185\u6e90\u6027\u86cb\u767d\u63d0\u53d6\u83b7\u5f97\u4e86\u6027\u8d28\u826f\u597d\u7684\u6837\u54c1\uff0c\u5e76\u5229\u7528\u5355\u9897\u7c92\u51b7\u51bb\u7535\u5b50\u663e\u5fae\u955c\u6280\u672f\uff0c\u7ee72015\u5e74\u7387\u5148\u62a5\u9053\u88c2\u6b96\u9175\u6bcd\u526a\u63a5\u4f53\u7684\u7ed3\u6784\u4e4b\u540e\uff0c\u57282016\u5e74\u53d6\u5f97\u91cd\u5927\u7a81\u7834\uff0c\u76f8\u7ee7\u89e3\u6790\u4e863\u4e2a\u5173\u952e\u5de5\u4f5c\u72b6\u6001\u4e0b\u526a\u63a5\u4f53\u7684\u8fd1\u539f\u5b50\u5206\u8fa8\u7387\u7ed3\u6784(\u53733.5\u57c3\u7684\u6fc0\u6d3b\u72b6\u6001\u526a\u63a5\u4f53Bact complex\u30013.4\u57c3\u7684\u7b2c\u4e00\u6b65\u50ac\u5316\u53cd\u5e94\u540e\u590d\u5408\u7269C complex\u4ee5\u53ca4.0\u57c3\u7684\u7b2c\u4e8c\u6b65\u50ac\u5316\u6fc0\u6d3b\u72b6\u6001\u4e0b\u7684C* complex)\u4ee5\u53ca\u4e00\u4e2a\u526a\u63a5\u4f53\u7ec4\u88c5\u8fc7\u7a0b\u4e2d\u91cd\u8981\u590d\u5408\u7269\u7684\u9ad8\u5206\u8fa8\u7387\u7ed3\u6784(\u53733.8\u57c3\u7684\u9884\u7ec4\u88c5\u590d\u5408\u7269U4\/U6.U5 tri-snRNP)\u3002\u8fd94\u9879\u8fdb\u5c55\u5747\u4ee5\u957f\u6587\u7684\u5f62\u5f0f\u5148\u540e\u53d1\u8868\u57282016\u5e74\u7684\u300a\u79d1\u5b66\u300b\u4e0a(<em>Science<\/em> 351:466-475; 353:895-904\uff1b353:904-911; aak9979)\u3002\u8fd94\u4e2a\u9ad8\u5206\u8fa8\u7387\u7ed3\u6784\u6240\u4ee3\u8868\u7684\u526a\u63a5\u4f53\u72b6\u6001\uff0c\u57fa\u672c\u8986\u76d6\u4e86RNA\u526a\u63a5\u7684\u5173\u952e\u50ac\u5316\u6b65\u9aa4\uff0c\u4ece\u5206\u5b50\u5c42\u9762\u89e3\u91ca\u4e86\u526a\u63a5\u4f53\u6267\u884cRNA\u526a\u63a5\u7684\u673a\u5236\uff0c\u6781\u5927\u5730\u63a8\u52a8\u4e86RNA\u526a\u63a5\u8fd9\u4e00\u57fa\u7840\u7814\u7a76\u9886\u57df\u7684\u53d1\u5c55\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12pt;\"><strong>6. \u53d1\u73b0\u7cbe\u5b50RNA\u53ef\u4f5c\u4e3a\u8bb0\u5fc6\u8f7d\u4f53\u5c06\u83b7\u5f97\u6027\u6027\u72b6\u8de8\u4ee3\u9057\u4f20<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12pt;\">\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u663e\u793a\uff0c\u968f\u7740\u751f\u6d3b\u73af\u5883\u548c\u996e\u98df\u7ed3\u6784\u7684\u5de8\u5927\u6539\u53d8\uff0c\u9ad8\u8102\u996e\u98df\u5bfc\u81f4\u7684\u80a5\u80d6\u7b49\u4ee3\u8c22\u6027\u75be\u75c5\uff0c\u53ef\u4ee5\u201c\u8bb0\u5fc6\u201d\u5728\u7cbe\u5b50\u4e2d\u5e76\u9057\u4f20\u7ed9\u4e0b\u4e00\u4ee3\uff0c\u5bfc\u81f4\u540e\u4ee3\u80a5\u80d6\u3002\u8fd9\u79cd\u83b7\u5f97\u6027\u9057\u4f20\u5f62\u5f0f\u5bf9\u4eba\u7c7b\u7e41\u884d\u53ca\u540e\u4ee3\u5065\u5eb7\u5177\u6709\u6df1\u8fdc\u7684\u5f71\u54cd\u3002\u7cbe\u5b50\u4ecb\u5bfc\u7684\u8fd9\u79cd\u83b7\u5f97\u6027\u9057\u4f20\u673a\u5236\u6d89\u53caDNA\u5e8f\u5217\u4e4b\u5916\u7684\u8868\u89c2\u9057\u4f20\u4fe1\u606f\u5728\u7cbe\u5b50\u4e2d\u7684\u5b58\u50a8\u53ca\u4f20\u9012\uff0c\u7834\u89e3\u8fd9\u7c7b\u8868\u89c2\u9057\u4f20\u4fe1\u606f\u662f\u672c\u9886\u57df\u7684\u4e00\u4e2a\u4e3b\u8981\u6311\u6218\u3002\u4e2d\u56fd\u79d1\u5b66\u9662\u9662\u58eb\u3001\u4e2d\u56fd\u79d1\u5b66\u9662\u52a8\u7269\u7814\u7a76\u6240\u7814\u7a76\u5458\u5468\u742a\u53ca\u6bb5\u6069\u594e\u7814\u7a76\u7ec4\u4e0e\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u751f\u547d\u79d1\u5b66\u7814\u7a76\u9662\u8425\u517b\u79d1\u5b66\u7814\u7a76\u6240\u7814\u7a76\u5458\u7fdf\u7426\u5dcd\u5408\u4f5c\uff0c\u57fa\u4e8e\u9ad8\u8102\u80aa\u996e\u98df\u5c0f\u9f20\u6a21\u578b\uff0c\u53d1\u73b0\u7cbe\u5b50\u4e2d\u4e00\u7c7b\u6765\u6e90\u4e8etRNA\u76845\u2019\u7aef\u5e8f\u5217\u7684\u3001\u5927\u5c0f\u5bcc\u96c6\u572830\u201434nt\u7684\u5c0fRNA (tsRNAs)\u5728\u9ad8\u8102\u996e\u98df\u4e0b\u53d1\u751f\u4e86\u8868\u8fbe\u8c31\u548cRNA\u4fee\u9970\u8c31\u7684\u663e\u8457\u6539\u53d8\u3002\u5206\u79bb\u9ad8\u8102\u5c0f\u9f20\u7cbe\u5b50\u4e2d\u7684tsRNAs\u7247\u6bb5\u5e76\u6ce8\u5c04\u5230\u6b63\u5e38\u53d7\u7cbe\u5375\u5185\uff0c\u53ef\u8bf1\u5bfcF1\u5b50\u4ee3\u4ea7\u751f\u4ee3\u8c22\u6027\u75be\u75c5\u3002\u9ad8\u8102\u5c0f\u9f20\u7cbe\u5b50\u7684tsRNAs\u8fdb\u5165\u53d7\u7cbe\u5375\u540e\u5bfc\u81f4\u65e9\u671f\u80da\u80ce\u53ca\u540e\u4ee3\u5c0f\u9f20\u80f0\u5c9b\u4e2d\u4ee3\u8c22\u901a\u8def\u57fa\u56e0\u53d1\u751f\u663e\u8457\u6539\u53d8\u3002\u8be5\u7814\u7a76\u7b2c\u4e00\u6b21\u4ece\u7cbe\u5b50RNA\u89d2\u5ea6\u4e3a\u7814\u7a76\u83b7\u5f97\u6027\u6027\u72b6\u7684\u8de8\u4ee3\u9057\u4f20\u73b0\u8c61\u5f00\u62d3\u4e86\u5168\u65b0\u7684\u89c6\u89d2\uff0c\u63d0\u51fa\u7cbe\u5b50tsRNAs\u662f\u4e00\u7c7b\u65b0\u7684\u7236\u672c\u8868\u89c2\u9057\u4f20\u56e0\u5b50\uff0c\u53ef\u4ecb\u5bfc\u83b7\u5f97\u6027\u4ee3\u8c22\u75be\u75c5\u7684\u8de8\u4ee3\u9057\u4f20\u3002\u76f8\u5173\u7814\u7a76\u8bba\u6587\u53d1\u8868\u57282016\u5e741\u670822\u65e5\u300a\u79d1\u5b66\u300b(<em>Science<\/em> [351(6271):397\u2014400])\u4e0a\u3002\u6587\u7ae0\u53d1\u8868\u4ee5\u540e\u88ab\u5e7f\u6cdb\u5f15\u7528\u548c\u8bc4\u4ef7\uff0c\u5f15\u8d77\u56fd\u9645\u5404\u5927\u5a92\u4f53\u7684\u5173\u6ce8\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12pt;\"><strong>7. \u7814\u5236\u51fa\u9996\u4e2a\u7a33\u5b9a\u53ef\u63a7\u7684\u5355\u5206\u5b50\u7535\u5b50\u5f00\u5173\u5668\u4ef6<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12pt;\">\u5229\u7528\u5355\u5206\u5b50\u6784\u5efa\u7535\u5b50\u5668\u4ef6\u5bf9\u7a81\u7834\u76ee\u524d\u534a\u5bfc\u4f53\u5668\u4ef6\u5fae\u5c0f\u5316\u53d1\u5c55\u7684\u74f6\u9888\u610f\u4e49\u91cd\u5927\u3002\u5b9e\u73b0\u53ef\u63a7\u7684\u5355\u5206\u5b50\u7535\u5b50\u5f00\u5173\u529f\u80fd\u662f\u9a8c\u8bc1\u5206\u5b50\u80fd\u5426\u4f5c\u4e3a\u6838\u5fc3\u7ec4\u4ef6\u5e94\u7528\u5230\u7535\u5b50\u5668\u4ef6\u4e2d\u7684\u5173\u952e\u3002\u81ea20\u4e16\u7eaa70\u5e74\u4ee3\u4ee5\u6765\uff0c\u8bbe\u8ba1\u6784\u7b51\u7a33\u5b9a\u53ef\u63a7\u7684\u5355\u5206\u5b50\u5668\u4ef6\uff0c\u63a2\u7d22\u5176\u4e0e\u5fae\u7535\u5b50\u5de5\u827a\u7684\u517c\u5bb9\u6027\uff0c\u5e76\u83b7\u5f97\u771f\u6b63\u610f\u4e49\u4e0a\u7684\u5206\u5b50\u7535\u5b50\u5f00\u5173\uff0c\u5728\u5f53\u4ee3\u7eb3\u7c73\u7535\u5b50\u5b66\u7814\u7a76\u4e2d\u5177\u6709\u91cd\u5927\u7684\u79d1\u5b66\u610f\u4e49\u3002\u5317\u4eac\u5927\u5b66\u5317\u4eac\u5206\u5b50\u79d1\u5b66\u56fd\u5bb6\u5b9e\u9a8c\u5ba4\u6559\u6388\u90ed\u96ea\u5cf0\u7814\u7a76\u7ec4\u539f\u521b\u6027\u5730\u53d1\u5c55\u4e86\u4ee5\u77f3\u58a8\u70ef\u4e3a\u7535\u6781\u3001\u901a\u8fc7\u5171\u4ef7\u952e\u8fde\u63a5\u7684\u7a33\u5b9a\u5355\u5206\u5b50\u5668\u4ef6\u7684\u5173\u952e\u5236\u5907\u65b9\u6cd5\uff0c\u89e3\u51b3\u4e86\u5355\u5206\u5b50\u5668\u4ef6\u5236\u5907\u96be\u3001\u7a33\u5b9a\u6027\u5dee\u7684\u96be\u9898\u3002\u5728\u6b64\u57fa\u7840\u4e0a\uff0c\u4ed6\u4eec\u4e0e\u7535\u5b50\u5b66\u7cfb\u5f90\u6d2a\u8d77\u7814\u7a76\u7ec4\u4ee5\u53ca\u7f8e\u56fd\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66Abraham Nitzan\u7b49\u5408\u4f5c\uff0c\u901a\u8fc7\u529f\u80fd\u5bfc\u5411\u7684\u5206\u5b50\u5de5\u7a0b\u5b66\u6210\u529f\u5730\u514b\u670d\u4e86\u4e8c\u82b3\u70ef\u5206\u5b50\u4e0e\u77f3\u58a8\u70ef\u7535\u6781\u95f4\u5f3a\u8026\u5408\u4f5c\u7528\u7684\u6838\u5fc3\u6311\u6218\u6027\u95ee\u9898\uff0c\u4ece\u800c\u7a81\u7834\u6027\u5730\u6784\u5efa\u4e86\u4e00\u7c7b\u5168\u53ef\u9006\u7684\u5149\u8bf1\u5bfc\u548c\u7535\u573a\u8bf1\u5bfc\u7684\u53cc\u6a21\u5f0f\u5355\u5206\u5b50\u5149\u7535\u5b50\u5668\u4ef6\u3002\u8fd9\u9879\u7814\u7a76\u5de5\u4f5c\u4f7f\u5f97\u5728\u4e2d\u56fd\u8bde\u751f\u4e86\u4e16\u754c\u9996\u4f8b\u771f\u5b9e\u7a33\u5b9a\u53ef\u63a7\u7684\u5355\u5206\u5b50\u7535\u5b50\u5f00\u5173\u5668\u4ef6\u3002\u77f3\u58a8\u70ef\u7535\u6781\u548c\u4e8c\u82b3\u70ef\u5206\u5b50\u7a33\u5b9a\u7684\u78b3\u9aa8\u67b6\u4ee5\u53ca\u7262\u56fa\u7684\u5206\u5b50\/\u7535\u6781\u95f4\u5171\u4ef7\u952e\u94fe\u63a5\u65b9\u5f0f\u4f7f\u8fd9\u4e9b\u5355\u5206\u5b50\u5f00\u5173\u5668\u4ef6\u5177\u6709\u7a7a\u524d\u7684\u5f00\u5173\u7cbe\u5ea6\u3001\u7a33\u5b9a\u6027\u548c\u53ef\u91cd\u73b0\u6027\uff0c\u5728\u672a\u6765\u9ad8\u5ea6\u96c6\u6210\u7684\u4fe1\u606f\u5904\u7406\u5668\u3001\u5206\u5b50\u8ba1\u7b97\u673a\u548c\u7cbe\u51c6\u5206\u5b50\u8bca\u65ad\u6280\u672f\u7b49\u65b9\u9762\u5177\u6709\u5de8\u5927\u7684\u5e94\u7528\u524d\u666f\u3002\u76f8\u5173\u7814\u7a76\u8bba\u6587\u53d1\u8868\u57282016\u5e746\u670817\u65e5\u300a\u79d1\u5b66\u300b(<em>Science<\/em> [352(6292):1443\u20141445])\u4e0a\u3002\u300a\u79d1\u5b66\u300b\u540c\u671f\u914d\u53d1\u8bc4\u8ff0\u6587\u7ae0\u8ba4\u4e3a\uff1a\u201c\u8be5\u7814\u7a76\u5c55\u793a\u4e86\u5728\u7eb3\u7c73\u5c3a\u5ea6\u4e0a\u5bf9\u7269\u8d28\u7684\u7cbe\u81f4\u63a7\u5236\u3002\u201d<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12pt;\"><strong>8. \u6784\u5efa\u51fa\u4e16\u754c\u4e0a\u9996\u4e2a\u975e\u4eba\u7075\u957f\u7c7b\u81ea\u95ed\u75c7\u6a21\u578b<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12pt;\">\u81ea\u95ed\u75c7(\u4e5f\u79f0\u5b64\u72ec\u75c7)\u662f\u4e00\u7c7b\u591a\u53d1\u4e8e\u9752\u5c11\u5e74\u7684\u53d1\u80b2\u6027\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\uff0c\u60a3\u8005\u8868\u73b0\u51fa\u793e\u4ea4\u969c\u788d\u3001\u91cd\u590d\u6027\u523b\u677f\u52a8\u4f5c\u7b49\u884c\u4e3a\u5f02\u5e38\uff0c\u76ee\u524d\u5c1a\u65e0\u6709\u6548\u7684\u836f\u7269\u6cbb\u7597\u53ca\u5e72\u9884\u65b9\u6cd5\u3002\u8fd1\u5e74\u6765\u4e16\u754c\u5404\u56fd\u5747\u53d1\u73b0\u81ea\u95ed\u75c7\u7684\u60a3\u75c5\u7387\u9010\u5e74\u5347\u9ad8\uff0c\u5f15\u8d77\u793e\u4f1a\u5404\u754c\u5e7f\u6cdb\u5173\u6ce8\u3002\u4e2d\u56fd\u4f5c\u4e3a\u4eba\u53e3\u5927\u56fd\uff0c\u9884\u8ba1\u5168\u56fd\u81ea\u95ed\u75c7\u60a3\u8005\u8fd1\u5343\u4e07\u3002\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u751f\u547d\u79d1\u5b66\u7814\u7a76\u9662\u795e\u7ecf\u79d1\u5b66\u7814\u7a76\u6240\u7814\u7a76\u5458\u4ec7\u5b50\u9f99\u7814\u7a76\u7ec4\u4e0e\u975e\u4eba\u7075\u957f\u7c7b\u5e73\u53f0\u5b59\u5f3a\u56e2\u961f\u5408\u4f5c\uff0c\u901a\u8fc7\u6784\u5efa\u643a\u5e26\u4eba\u7c7b\u81ea\u95ed\u75c7\u57fa\u56e0MECP2\u7684\u8f6c\u57fa\u56e0\u7334\u6a21\u578b\u5e76\u5bf9\u8f6c\u57fa\u56e0\u7334\u8fdb\u884c\u5206\u5b50\u9057\u4f20\u5b66\u4e0e\u884c\u4e3a\u5b66\u5206\u6790\uff0c\u53d1\u73b0MECP2\u8f6c\u57fa\u56e0\u7334\u8868\u73b0\u51fa\u7c7b\u4f3c\u4e8e\u4eba\u7c7b\u81ea\u95ed\u75c7\u7684\u523b\u677f\u52a8\u4f5c\u4e0e\u793e\u4ea4\u969c\u788d\u7b49\u884c\u4e3a\u3002\u4ed6\u4eec\u5e76\u9996\u6b21\u5728\u7075\u957f\u7c7b\u4e2d\u6210\u529f\u901a\u8fc7\u7cbe\u5de2\u5f02\u4f53\u79fb\u690d\u7684\u65b9\u6cd5\u52a0\u5feb\u7334\u7c7b\u7e41\u6b96\u5468\u671f\uff0c\u5386\u65f6\u4e09\u5e74\u534a\u5f97\u5230\u4e86\u643a\u5e26\u4eba\u7c7bMECP2\u57fa\u56e0\u7684\u7b2c\u4e8c\u4ee3\u8f6c\u57fa\u56e0\u7334\uff0c\u4e14\u53d1\u73b0\u5176\u5728\u793e\u4ea4\u884c\u4e3a\u65b9\u9762\u8868\u73b0\u51fa\u4e86\u4e0e\u4eb2\u4ee3\u76f8\u540c\u7684\u81ea\u95ed\u75c7\u6837\u8868\u578b\u3002\u8fd9\u662f\u4e16\u754c\u4e0a\u9996\u4e2a\u81ea\u95ed\u75c7\u7684\u975e\u4eba\u7075\u957f\u7c7b\u6a21\u578b\uff0c\u4e3a\u6df1\u5165\u7814\u7a76\u81ea\u95ed\u75c7\u7684\u75c5\u7406\u4e0e\u63a2\u7d22\u53ef\u80fd\u7684\u6cbb\u7597\u5e72\u9884\u65b9\u6cd5\u505a\u51fa\u4e86\u91cd\u8981\u8d21\u732e\u3002\u76f8\u5173\u7814\u7a76\u8bba\u6587\u53d1\u8868\u57282016\u5e742\u67084\u65e5\u300a\u81ea\u7136\u300b(<em>Nature<\/em>[530(7588):98\u2014102])\u4e0a\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12pt;\"><strong>9. \u63ed\u793a\u80da\u80ce\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u5173\u952e\u4fe1\u53f7\u901a\u8def\u7684\u8868\u89c2\u9057\u4f20\u8c03\u63a7\u673a\u7406<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12pt;\">\u52a8\u690d\u7269\u4ece\u5355\u7ec6\u80de\u53d7\u7cbe\u5375\u53d1\u80b2\u6210\u4e3a\u9ad8\u5ea6\u590d\u6742\u7684\u751f\u7269\u4f53\u662f\u4e00\u4e2a\u5947\u5999\u7684\u8fc7\u7a0b\u3002\u54fa\u4e73\u52a8\u7269\u57fa\u56e0\u7ec4DNA\u4e2d\u76845-\u7532\u57fa\u80de\u5627\u5576\u4f5c\u4e3a\u4e00\u79cd\u7a33\u5b9a\u5b58\u5728\u7684\u8868\u89c2\u9057\u4f20\u4fee\u9970\uff0c\u7531DNA\u7532\u57fa\u8f6c\u79fb\u9176(DNMTs)\u50ac\u5316\u4ea7\u751f\u3002\u8fd1\u5e74\u7814\u7a76\u53d1\u73b0\uff0cTET\u53cc\u52a0\u6c27\u9176\u5bb6\u65cf\u86cb\u767d(TET1\/2\/3)\u53ef\u4ee5\u6c27\u53165-\u7532\u57fa\u80de\u5627\u5576\uff0c\u5f15\u53d1DNA\u53bb\u7532\u57fa\u5316\u3002\u867d\u7136DNA\u7532\u57fa\u5316\u5728\u54fa\u4e73\u52a8\u7269\u57fa\u56e0\u5370\u8bb0\u548cX\u67d3\u8272\u4f53\u5931\u6d3b\u7b49\u751f\u547d\u6d3b\u52a8\u8fc7\u7a0b\u4e2d\u53c2\u4e0e\u57fa\u56e0\u8868\u8fbe\u7684\u8c03\u63a7\uff0c\u4f46\u662fDNA\u7532\u57fa\u5316\u4ee5\u53caTET\u53cc\u52a0\u6c27\u9176\u4ecb\u5bfc\u7684\u53bb\u7532\u57fa\u5316\u5728\u5c0f\u9f20\u80da\u80ce\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u7a76\u7adf\u8d77\u4ec0\u4e48\u4f5c\u7528\u8fd8\u4e0d\u6e05\u695a\u3002\u4e2d\u56fd\u79d1\u5b66\u9662\u9662\u58eb\u3001\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u751f\u547d\u79d1\u5b66\u7814\u7a76\u9662\u751f\u7269\u5316\u5b66\u4e0e\u7ec6\u80de\u751f\u7269\u5b66\u7814\u7a76\u6240\u7814\u7a76\u5458\u5f90\u56fd\u826f\u7814\u7a76\u7ec4\u4e0e\u7f8e\u56fd\u5a01\u65af\u5eb7\u661f\u5927\u5b66\u6559\u6388\u5b59\u6b23\u3001\u5317\u4eac\u5927\u5b66\u6559\u6388\u6c64\u5bcc\u916c\u7b49\u5408\u4f5c\uff0c\u5229\u7528\u751f\u6b96\u7cfb\u7279\u5f02\u6027\u6572\u9664\u5c0f\u9f20\u5f97\u5230Tet\u57fa\u56e0\u4e09\u6572\u9664\u80da\u80ce\uff0c\u901a\u8fc7\u4e00\u7cfb\u5217\u5f62\u6001\u53d1\u80b2\u7279\u5f81\u7684\u68c0\u6d4b\uff0c\u7ed3\u5408\u57fa\u56e0\u529f\u80fd\u4e92\u8865\u5206\u6790\uff0c\u89e3\u6790\u4e86TET\u7f3a\u5931\u9020\u6210\u80da\u80ce\u6b7b\u4ea1\u7684\u673a\u5236\uff0c\u53d1\u73b0\u4e86TET\u4e09\u4e2a\u6210\u5458\u4e4b\u95f4\u529f\u80fd\u4e0a\u76f8\u4e92\u534f\u4f5c\uff0c\u4ecb\u5bfc\u7684DNA\u53bb\u7532\u57fa\u5316\u4e0eDNMT\u4ecb\u5bfc\u7684DNA\u7532\u57fa\u5316\u76f8\u4e92\u62ee\u6297\uff0c\u901a\u8fc7\u8c03\u63a7Lefty-Nodal\u4fe1\u53f7\u901a\u8def\u63a7\u5236\u80da\u80ce\u539f\u80a0\u8fd0\u52a8\u3002\u8be5\u5de5\u4f5c\u4ece\u957f\u671f\u56f0\u6270\u53d1\u80b2\u751f\u7269\u5b66\u9886\u57df\u7684\u57fa\u672c\u91cd\u5927\u95ee\u9898\u51fa\u53d1\uff0c\u7740\u773c\u4e8e\u4eba\u7c7b\u65b0\u751f\u513f\u51fa\u751f\u7f3a\u9677\u7684\u53ef\u80fd\u673a\u7406\u548c\u9632\u6cbb\uff0c\u7b2c\u4e00\u6b21\u7cfb\u7edf\u5730\u63ed\u793a\u4e86\u80da\u80ce\u53d1\u80b2\u8fc7\u7a0b\u4e2d\u5173\u952e\u4fe1\u53f7\u901a\u8def\u7684\u8868\u89c2\u9057\u4f20\u8c03\u63a7\u673a\u7406\uff0c\u4e3a\u53d1\u80b2\u751f\u7269\u5b66\u7684\u57fa\u672c\u539f\u7406\u63d0\u4f9b\u4e86\u5d2d\u65b0\u7684\u8ba4\u8bc6\u3002\u76f8\u5173\u7814\u7a76\u8bba\u6587\u53d1\u8868\u57282016\u5e7410\u670827\u65e5\u300a\u81ea\u7136\u300b(<em>Nature <\/em>[538:528\u2014532])\u4e0a\u3002<\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12pt;\"><strong>10. \u63ed\u793a\u6c34\u7684\u6838\u91cf\u5b50\u6548\u5e94<\/strong><\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"font-size: 12pt;\">\u5bf9\u4e8e\u5927\u591a\u6570\u6750\u6599\u4f53\u7cfb\u800c\u8a00\uff0c\u4e00\u822c\u53ea\u9700\u8981\u8003\u8651\u7535\u5b50\u7684\u91cf\u5b50\u5316\uff0c\u539f\u5b50\u6838\u5219\u88ab\u5f53\u4f5c\u7ecf\u5178\u7c92\u5b50\u6765\u5904\u7406\u3002\u7136\u800c\uff0c\u6c34\u4e2d\u4e09\u5206\u4e4b\u4e8c\u7684\u539f\u5b50\u662f\u6c22\u539f\u5b50\uff0c\u7531\u4e8e\u6c22\u539f\u5b50\u6838\u7684\u8d28\u91cf\u5f88\u5c0f\uff0c\u5176\u91cf\u5b50\u6548\u5e94\u4f1a\u5f02\u5e38\u663e\u8457\u3002\u6c22\u6838\u7684\u91cf\u5b50\u6548\u5e94\u5bf9\u6c34\u7684\u6c22\u952e\u76f8\u4e92\u4f5c\u7528\u5230\u5e95\u6709\u591a\u5927\u5f71\u54cd\uff1f\u6216\u8005\u8bf4\u6c22\u952e\u7684\u91cf\u5b50\u6210\u5206\u6709\u591a\u5927\uff1f\u88ab\u8ba4\u4e3a\u662f\u63ed\u5f00\u6c34\u7684\u5965\u79d8\u6240\u9700\u8981\u56de\u7b54\u7684\u5173\u952e\u95ee\u9898\u4e4b\u4e00\u3002\u7531\u4e8e\u6c22\u6838\u7684\u91cf\u5b50\u5316\u7814\u7a76\u65e0\u8bba\u5bf9\u4e8e\u5b9e\u9a8c\u8fd8\u662f\u7406\u8bba\u90fd\u975e\u5e38\u5177\u6709\u6311\u6218\u6027\uff0c\u8fd9\u4e2a\u95ee\u9898\u4e00\u76f4\u6ca1\u6709\u5f97\u5230\u5f88\u597d\u7684\u89e3\u7b54\u3002\u4e2d\u56fd\u79d1\u5b66\u9662\u9662\u58eb\u3001\u5317\u4eac\u5927\u5b66\u7269\u7406\u5b66\u9662\u6559\u6388\u738b\u6069\u54e5\uff0c\u4e0e\u6c5f\u9896\u7814\u7a76\u7ec4\u53ca\u5408\u4f5c\u8005\uff0c\u5728\u76f8\u5173\u5b9e\u9a8c\u6280\u672f\u548c\u7406\u8bba\u65b9\u6cd5\u4e0a\u5206\u522b\u53d6\u5f97\u7a81\u7834\uff1a\u53d1\u5c55\u4e86\u4e00\u5957\u201c\u9488\u5c16\u589e\u5f3a\u7684\u975e\u5f39\u6027\u7535\u5b50\u96a7\u7a7f\u8c31\u201d\u6280\u672f\uff0c\u83b7\u5f97\u4e86\u5355\u4e2a\u6c34\u5206\u5b50\u7684\u9ad8\u5206\u8fa8\u632f\u52a8\u8c31\uff0c\u5e76\u7531\u6b64\u6d4b\u5f97\u4e86\u5355\u4e2a\u6c22\u952e\u7684\u5f3a\u5ea6\uff1b\u5f00\u53d1\u4e86\u57fa\u4e8e\u7b2c\u4e00\u6027\u539f\u7406\u7684\u8def\u5f84\u79ef\u5206\u5206\u5b50\u52a8\u529b\u5b66\u65b9\u6cd5\uff0c\u5b9e\u73b0\u4e86\u5bf9\u7535\u5b50\u91cf\u5b50\u6001\u548c\u539f\u5b50\u6838\u91cf\u5b50\u6001\u7684\u7cbe\u786e\u63cf\u8ff0\u3002\u57fa\u4e8e\u6b64\uff0c\u4ed6\u4eec\u5728\u56fd\u9645\u4e0a\u7387\u5148\u6d4b\u5b9a\u4e86\u6c22\u952e\u7684\u91cf\u5b50\u6210\u5206\uff0c\u9996\u6b21\u5728\u539f\u5b50\u5c3a\u5ea6\u63ed\u793a\u4e86\u6c34\u7684\u6838\u91cf\u5b50\u6548\u5e94\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u6c22\u952e\u7684\u91cf\u5b50\u6210\u5206\u53ef\u8fdc\u5927\u4e8e\u5ba4\u6e29\u7684\u70ed\u80fd\uff0c\u6c22\u6838\u7684\u201c\u975e\u7b80\u8c10\u96f6\u70b9\u8fd0\u52a8\u201d\u4f1a\u5f31\u5316\u5f31\u6c22\u952e\u3001\u5f3a\u5316\u5f3a\u6c22\u952e\uff0c\u8fd9\u4e2a\u7269\u7406\u56fe\u50cf\u5bf9\u4e8e\u5404\u79cd\u6c22\u952e\u4f53\u7cfb\u5177\u6709\u76f8\u5f53\u7684\u666e\u9002\u6027\u3002\u8be5\u5de5\u4f5c\u662f\u5bf9\u201c\u6c22\u952e\u7684\u91cf\u5b50\u6210\u5206\u7a76\u7adf\u6709\u591a\u5927\u201d\u8fd9\u4e00\u7269\u8d28\u79d1\u5b66\u57fa\u672c\u95ee\u9898\u7684\u9996\u6b21\u5b9a\u91cf\u89e3\u7b54\uff0c\u6f84\u6e05\u4e86\u5b66\u672f\u754c\u957f\u671f\u4e89\u8bba\u7684\u6c22\u952e\u7684\u91cf\u5b50\u672c\u8d28\uff0c\u5c06\u6709\u52a9\u4e8e\u7406\u89e3\u6c34\u548c\u5176\u4ed6\u6c22\u952e\u4f53\u7cfb\u7684\u5f88\u591a\u53cd\u5e38\u7279\u6027\u3002\u76f8\u5173\u7814\u7a76\u8bba\u6587\u53d1\u8868\u57282016\u5e744\u670815\u65e5\u300a\u79d1\u5b66\u300b(<em>Science <\/em>[352(6283):321\u2014325])\u4e0a\u3002\u8be5\u7814\u7a76\u88ab\u5ba1\u7a3f\u4eba\u8bc4\u4ef7\u4e3a\u201c\u6c22\u6838\u91cf\u5b50\u6548\u5e94\u7814\u7a76\u7684\u5b9e\u9a8c\u6770\u4f5c\u201d\uff1b\u6838\u91cf\u5b50\u6548\u5e94\u7814\u7a76\u9886\u57df\u6743\u5a01\u4e13\u5bb6\u5fb7\u56fd\u7684Dominik Marx\u6559\u6388\u8ba4\u4e3a\u8be5\u5de5\u4f5c\u201c\u5b8c\u6210\u4e86\u96be\u4ee5\u7f6e\u4fe1\u7684\u4efb\u52a1\u201d\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt;\"><strong>\u6765\u6e90\uff1a\u4e2d\u56fd\u79d1\u5b66\u9662\u79d1\u5b66\u4f20\u64ad\u5c40 &amp; \u79d1\u6280\u65e5\u62a5-\u9510\u52a8\u6e90<\/strong><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e2d\u79d1\u9662\u591a\u9879\u6210\u679c\u5165\u90092016\u5e74\u5ea6\u4e2d\u56fd\u79d1\u5b66\u5341\u5927\u8fdb\u5c55<\/p>\n","protected":false},"author":70,"featured_media":4755,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[416],"class_list":["post-4754","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-info","tag-416"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.leadingtec.cn\/wp-json\/wp\/v2\/posts\/4754"}],"collection":[{"href":"https:\/\/www.leadingtec.cn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.leadingtec.cn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.leadingtec.cn\/wp-json\/wp\/v2\/users\/70"}],"replies":[{"embeddable":true,"href":"https:\/\/www.leadingtec.cn\/wp-json\/wp\/v2\/comments?post=4754"}],"version-history":[{"count":0,"href":"https:\/\/www.leadingtec.cn\/wp-json\/wp\/v2\/posts\/4754\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.leadingtec.cn\/wp-json\/wp\/v2\/media\/4755"}],"wp:attachment":[{"href":"https:\/\/www.leadingtec.cn\/wp-json\/wp\/v2\/media?parent=4754"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.leadingtec.cn\/wp-json\/wp\/v2\/categories?post=4754"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.leadingtec.cn\/wp-json\/wp\/v2\/tags?post=4754"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}