{"id":4869,"date":"2017-03-24T11:20:56","date_gmt":"2017-03-24T03:20:56","guid":{"rendered":"http:\/\/www.leadingtec.cn\/?p=4869"},"modified":"2017-03-24T11:20:56","modified_gmt":"2017-03-24T03:20:56","slug":"green-algae-gene-optogenetics","status":"publish","type":"post","link":"https:\/\/www.leadingtec.cn\/green-algae-gene-optogenetics.html","title":{"rendered":"\u4e2d\u56fd\u79d1\u5b66\u5bb6\u628a\u7eff\u85fb\u57fa\u56e0\u8f6c\u5165\u4eba\u4f53\u6cbb\u7597\u75be\u75c5"},"content":{"rendered":"

\u7531\u4e8e\u5317\u65b9\u7684\u5929\u6c14\u5f00\u59cb\u8f6c\u6696\uff0c\u5c0f\u5f3a\u5f00\u59cb\u6d3b\u8dc3\u8d77\u6765\u3002\u6709\u5929\u665a\u4e0a\u8fdb\u95e8\u5750\u4e0b\u6765\u4e4b\u540e\uff0c\u53d1\u73b0\u95e8\u53e3\u8db4\u7740\u4e00\u53ea\u5c0f\u5f3a\uff0c\u4e00\u52a8\u4e0d\u52a8\u3002\u5b83\u663e\u7136\u662f\u53d7\u5230\u5f00\u95e8\u7684\u60ca\u5413\uff0c\u672c\u80fd\u7684\u9759\u6b62\u4e0b\u6765\uff0c\u7b49\u5230\u5468\u56f4\u7684\u6c14\u6c1b\u7a0d\u5fae\u6b63\u5e38\uff0c\u518d\u4f3a\u673a\u9003\u8d70\u3002<\/span><\/p>\n

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\"\u5149\u9057\u4f20\u5b66\"<\/a>
<\/span> \u5149\u9057\u4f20\u5b66<\/span><\/figcaption><\/figure>\n

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\u65e9\u57282002\u5e74\uff0c\u5fb7\u56fd\u79d1\u5b66\u5bb6Peter Hegemann\u56e2\u961f\u5728\u7eff\u85fb\u4e2d\u53d1\u73b0\u4e86\u4e00\u79cd\u86cb\u767d\u8d28\uff08Channelrhodopsin-1\uff09\uff0c\u8fd9\u79cd\u86cb\u767d\u8d28\u5206\u5e03\u5728\u7eff\u85fb\u7ec6\u80de\u7684\u8868\u9762\uff0c\u53ef\u4ee5\u5c06\u5149\u4fe1\u53f7\u8f6c\u6362\u6210\u7535\u4fe1\u53f7\uff0c\u6307\u5f15\u7eff\u85fb\u6e38\u52a8\u5230\u5149\u7ebf\u5145\u8db3\u7684\u5730\u65b9\u3002Hegemann\u56e2\u961f\u7684\u8fd9\u4e00\u91cd\u8981\u7814\u7a76\u6210\u679c\uff0c\u520a\u767b\u5728\u300a\u79d1\u5b66\u300b\u6742\u5fd7\u4e0a\u3002<\/span><\/p>\n

\u770b\u5230Hegemann\u56e2\u961f\u7684\u7814\u7a76\u6210\u679c\u4e4b\u540e\uff0cStanford\u795e\u7ecf\u79d1\u5b66\u5bb6Karl Deisseroth\u548c\u540c\u4e8bEdward Boyden\u840c\u751f\u7684\u7b2c\u4e00\u4e2a\u5ff5\u5934\u5c31\u662f\u628a\u8fd9\u79cd\u86cb\u767d\u5b9a\u5411\u8f6c\u5230\u52a8\u7269\u7684\u795e\u7ecf\u7ec6\u80de\u4e2d\uff0c\u8fd9\u6837\u5c31\u53ef\u4ee5\u901a\u8fc7\u5149\u7167\u7cbe\u51c6\u7684\u63a7\u5236\u5927\u8111\u7684\u6d3b\u52a8\u3002<\/span><\/p>\n

\u4e8e\u662f\uff0c\u5728Deisseroth\u3001Boyden\u548c\u5f20\u950b\u7684\u52aa\u529b\u4e0b\uff0c\u4ed6\u4eec\u7ec8\u4e8e\u5b9e\u73b0\u4e86\u7cbe\u51c6\u6fc0\u6d3b\u7279\u5b9a\u795e\u7ecf\u7ec6\u80de\u3002\u5149\u9057\u4f20\u5b66\u5c31\u8fd9\u6837\u8bde\u751f\u4e86\u30022011\u5e74\u300a\u81ea\u7136\u00b7\u65b9\u6cd5\u300b\u5c06\u5149\u9057\u4f20\u5b66\u9009\u4e3a\u5e74\u5ea6\u6280\u672f\uff0c2015\u5e74\u5e95\uff0cDeisseroth\u548cBoyden\u5171\u540c\u83b7\u5f97\u4e86\u751f\u547d\u79d1\u5b66\u91cd\u5927\u7a81\u7834\u5956\u3002<\/span><\/p>\n

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2016\u5e74\uff0c\u5c31\u804c\u4e8e\u7f8e\u56fd\u97e6\u6069\u5dde\u7acb\u5927\u5b66\u548cRetroSense Therapeutics\u7684\u4e2d\u56fd\u79d1\u5b66\u5bb6\u6f58\u5353\u534e\u6559\u6388\uff0c\u4ee5\u53ca\u5176\u7814\u7a76\u56e2\u961f\u7ec8\u4e8e\u5c06\u8fd9\u4e00\u9769\u547d\u6027\u7684\u6280\u672f\u5e26\u5230\u4e86\u4e34\u5e8a\u3002<\/span><\/p>\n

\"\u6f58\u5353\u534e\u6559\u6388\"<\/a>
<\/span> \u6f58\u5353\u534e\u6559\u6388<\/span><\/figcaption><\/figure>\n

\u5728RetroSense Therapeutics\u6f58\u5353\u534e\u6559\u6388\u7684\u4e3b\u5bfc\u4e0b\uff0c2016\u5e742\u6708\u5e95\uff0c\u4e00\u540d\u56e0\u89c6\u7f51\u819c\u8272\u7d20\u53d8\u6027\uff08retinitis pigmentosa\uff0cRP\uff09\u4e27\u5931\u89c6\u529b\u7684Texas\u5973\u6027\uff0c\u5df2\u7ecf\u63a5\u53d7\u5149\u9057\u4f20\u5b66\u6cbb\u7597\uff0c\u6210\u4e3a\u5149\u9057\u4f20\u5b66\u6cbb\u7597\u7684\u5168\u7403\u7b2c\u4e00\u4eba\u3002<\/span><\/p>\n

RP\u662f\u4e00\u79cd\u5177\u6709\u660e\u663e\u9057\u4f20\u503e\u5411\u7684\u6162\u6027\u3001\u8fdb\u884c\u6027\u89c6\u7f51\u819c\u8272\u7d20\u4e0a\u76ae\u548c\u5149\u611f\u53d7\u5668\u7684\u53d8\u6027\u75be\u75c5\u3002\u76ee\u524d\u7684\u7814\u7a76\u8868\u660e\uff0c\u6709100\u591a\u79cd\u57fa\u56e0\u7a81\u53d8\u4f1a\u5f15\u8d77RP\u3002RP\u60a3\u8005\u7531\u4e8e\u611f\u5149\u7ec6\u80de\u53d7\u635f\uff0c\u65e0\u6cd5\u5c06\u5149\u4fe1\u53f7\u8f6c\u6362\u6210\u7535\u4fe1\u53f7\uff0c\u5e76\u901a\u8fc7\u795e\u7ecf\u4f20\u9012\u7ed9\u5927\u8111\uff0c\u6240\u4ee5\u770b\u4e0d\u89c1\u3002\u76ee\u524d\u56e0RP\u5f15\u8d77\u7684\u5931\u660e\u8fd8\u6ca1\u6709\u6709\u6548\u7684\u6cbb\u7597\u529e\u6cd5\u3002<\/span><\/p>\n

\u636e\u7edf\u8ba1\uff0c\u5728\u7f8e\u56fd\u6709\u8d85\u8fc7100\u4e07\u7684\u76f2\u4eba\uff0c\u5176\u4e2d\u7ea610\u4e07\u76f2\u4eba\u56e0\u4e3a\u89c6\u7f51\u819c\u8272\u7d20\u53d8\u6027\uff08retinitis pigmentosa\uff0cRP\uff09\u4e27\u5931\u89c6\u529b\u3002\u6839\u636e\u6211\u56fd\u90e8\u5206\u5730\u533a\u8c03\u67e5\u8d44\u6599\uff0cRP\u7fa4\u4f53\u60a3\u75c5\u7387\u7ea6\u4e3a1\/3500\uff0c\u603b\u60a3\u75c5\u4eba\u6570\u5e94\u8be5\u572840\u4e07\u4ee5\u4e0a\u3002<\/span><\/p>\n

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RetroSense Therapeutics\u5728\u672c\u6b21\u6cbb\u7597\u4e2d\u4f7f\u7528\u7684\u836f\u7269\u662fRST-001\uff0c\u5c5e\u4e8e\u57fa\u56e0\u6cbb\u7597\u836f\u7269\u3002\u5373\u4f7f\u7528\u5bf9\u4eba\u4f53\u65e0\u5bb3\u7684\u75c5\u6bd2\uff0c\u5c06\u7eff\u85fb\u7684\u611f\u5149\u86cb\u767d\u8f6c\u5230\u773c\u775b\u7279\u5b9a\u7684\u7ec6\u80de\u4e2d\uff0c\u4f7f\u8be5\u7ec6\u80de\u5177\u5907\u5c06\u5149\u4fe1\u53f7\u8f6c\u6362\u6210\u7535\u4fe1\u53f7\u7684\u529f\u80fd\uff0c\u9876\u66ff\u53d7\u635f\u611f\u5149\u7ec6\u80de\u7684\u5de5\u4f5c\u3002\u7531\u4e8e\u76ee\u524d\u6ca1\u6709\u6cbb\u7597RP\u7684\u836f\u7269\uff0c\u56e0\u6b64RetroSense Therapeutics\u7684RST-001\u88abFDA\u6388\u4e88\u201c\u5b64\u513f\u836f\u201d\u79f0\u53f7\u3002<\/span><\/p>\n

\u867d\u7136\u5149\u9057\u4f20\u5b66\u7684\u8bde\u751f\u4e0d\u8fc7\u5341\u4f59\u5e74\u7684\u65f6\u95f4\uff0c\u4f46\u662f\u5e94\u7528\u7684\u9886\u57df\u5df2\u7ecf\u975e\u5e38\u5e7f\u6cdb\u3002\u9664\u4e86\u6cbb\u7597\u773c\u75be\u4e4b\u5916\uff0c\u76ee\u524d\u53e6\u4e00\u4e2a\u88ab\u770b\u597d\u7684\u9886\u57df\u662f\u75bc\u75db\u7684\u6cbb\u7597\u3002<\/span><\/p>\n

\u636e\u7edf\u8ba1\uff0c\u76ee\u524d\u75bc\u75db\u5df2\u7ecf\u6210\u4e3a\u7f8e\u56fd\u4eba\u6c11\u770b\u533b\u751f\u6700\u5e38\u89c1\u7684\u539f\u56e0\uff0c\u7f8e\u56fd\u6bcf\u5e74\u5728\u6cbb\u7597\u75bc\u75db\u4e0a\u7684\u5065\u5eb7\u8d39\u7528\u8d85\u8fc76350\u4ebf\u7f8e\u5143\u3002\u5bf9\u4e8e\u5f88\u591a\u75bc\u75db\uff0c\u533b\u751f\u90fd\u662f\u7d20\u624b\u65e0\u7b56\u3002\u6210\u7acb\u4e8e2010\u5e74\u7684Circuit Therapeutics\uff0c\u6b63\u662f\u770b\u51c6\u4e86\u8fd9\u4e00\u5546\u673a\uff0c\u6253\u7b97\u5229\u7528\u5149\u9057\u4f20\u5b66\u5bf9\u795e\u7ecf\u7ec6\u80de\u7684\u7cbe\u51c6\u63a7\u5236\u6765\u6cbb\u7597\u75bc\u75db\u3002<\/span><\/p>\n

\u5982\u679cCircuit Therapeutics\u4f7f\u7528\u5149\u9057\u4f20\u5b66\u6cbb\u7597\u75bc\u75db\u594f\u6548\u7684\u8bdd\uff0c\u90a3\u4e48\u5728\u672a\u6765\uff0c\u533b\u751f\u6cbb\u7597\u75bc\u75db\u53ea\u9700\u8981\u5728\u75bc\u75db\u90e8\u4f4d\u7ed9\u60a3\u8005\u6ce8\u5c04\u643a\u5e26\u611f\u5149\u86cb\u767d\u7684\u75c5\u6bd2\uff0c\u7136\u540e\u5728\u5149\u4e0b\u7167\u4e00\u7167\u5c31\u4e0d\u75bc\u4e86\u3002<\/span><\/p>\n

\u76ee\u524d\u9664\u4e86RetroSense Therapeutics\u548cCircuit Therapeutics\u4e4b\u5916\uff0c\u8fd8\u6709\u5149\u9057\u4f20\u5b66\u53d1\u660e\u4eba\u3001MIT\u795e\u7ecf\u751f\u7269\u5b66\u6559\u6388Edward Boyden\u4e8e2007\u5e74\u521b\u529e\u7684Eos Neuroscience\uff0c\u4e5f\u5728\u5f00\u5c55\u5149\u9057\u4f20\u5b66\u6cbb\u7597\u773c\u90e8\u75be\u75c5\u53ca\u75bc\u75db\u7684\u4e34\u5e8a\u524d\u7814\u7a76\u3002<\/span><\/p>\n

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