{"id":4869,"date":"2017-03-24T11:20:56","date_gmt":"2017-03-24T03:20:56","guid":{"rendered":"http:\/\/www.leadingtec.cn\/?p=4869"},"modified":"2017-03-24T11:20:56","modified_gmt":"2017-03-24T03:20:56","slug":"green-algae-gene-optogenetics","status":"publish","type":"post","link":"https:\/\/www.leadingtec.cn\/green-algae-gene-optogenetics.html","title":{"rendered":"\u4e2d\u56fd\u79d1\u5b66\u5bb6\u628a\u7eff\u85fb\u57fa\u56e0\u8f6c\u5165\u4eba\u4f53\u6cbb\u7597\u75be\u75c5"},"content":{"rendered":"<p><span style=\"font-size: 12pt;\">\u7531\u4e8e\u5317\u65b9\u7684\u5929\u6c14\u5f00\u59cb\u8f6c\u6696\uff0c\u5c0f\u5f3a\u5f00\u59cb\u6d3b\u8dc3\u8d77\u6765\u3002\u6709\u5929\u665a\u4e0a\u8fdb\u95e8\u5750\u4e0b\u6765\u4e4b\u540e\uff0c\u53d1\u73b0\u95e8\u53e3\u8db4\u7740\u4e00\u53ea\u5c0f\u5f3a\uff0c\u4e00\u52a8\u4e0d\u52a8\u3002\u5b83\u663e\u7136\u662f\u53d7\u5230\u5f00\u95e8\u7684\u60ca\u5413\uff0c\u672c\u80fd\u7684\u9759\u6b62\u4e0b\u6765\uff0c\u7b49\u5230\u5468\u56f4\u7684\u6c14\u6c1b\u7a0d\u5fae\u6b63\u5e38\uff0c\u518d\u4f3a\u673a\u9003\u8d70\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt;\">\u5728\u81ea\u7136\u754c\u4e2d\uff0c\u6709\u5f88\u591a\u52a8\u7269\u90fd\u62e5\u6709\u8fd9\u6837\u7684\u672c\u80fd\uff0c\u6bd4\u5982\u8bf4\u591c\u95f4\u884c\u8d70\u5728\u516c\u8def\u4e0a\u7684\u9e7f\uff0c\u53d7\u5230\u706f\u5149\u7684\u60ca\u5413\uff0c\u4f1a\u505c\u5728\u9a6c\u8def\u4e2d\u95f4\uff1b\u5916\u51fa\u89c5\u98df\u7684\u8001\u9f20\uff0c\u770b\u5230\u56db\u5904\u89c5\u98df\u7684\u732b\uff0c\u4e5f\u4f1a\u56e0\u60ca\u5413\u800c\u505c\u4e0b\u811a\u6b65\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt;\">\u79d1\u7814\u4eba\u5458\u5bf9\u52a8\u7269\u7684\u8fd9\u4e9b\u884c\u4e3a\u6709\u6781\u5927\u7684\u5174\u8da3\uff0c\u56e0\u4e3a\u5982\u679c\u80fd\u5f04\u660e\u767d\u5f15\u8d77\u8fd9\u4e9b\u884c\u4e3a\u7684\u673a\u5236\uff0c\u90a3\u4e48\u5f88\u591a\u795e\u7ecf\u6027\u75be\u75c5\u5c31\u6709\u671b\u6cbb\u6108\u4e86\u3002\u4e8e\u662f\u79d1\u5b66\u5bb6\u53d1\u660e\u4e86\u4e00\u79cd\u53ef\u4ee5\u64cd\u7eb5\u5927\u8111\u7684\u65b0\u6280\u672f\uff0c\u5b83\u53ef\u4ee5\u8ba9\u5c0f\u9f20\u5728\u770b\u5230\u89c5\u98df\u7684\u732b\u4e4b\u540e\uff0c\u4ecd\u65e7\u80fd\u591f\u95f2\u5ead\u4fe1\u6b65\u3002\u8fd9\u79cd\u64cd\u7eb5\u5927\u8111\u7684\u9ed1\u79d1\u6280\u53eb\u505a\u5149\u9057\u4f20\u5b66\uff08Optogenetics\uff09\u3002<\/span><\/p>\n<figure id=\"attachment_4870\" aria-describedby=\"caption-attachment-4870\" style=\"width: 366px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.leadingtec.cn\/wp-content\/uploads\/2017\/03\/2016040514183398.png\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-4870\" src=\"https:\/\/www.leadingtec.cn\/wp-content\/uploads\/2017\/03\/2016040514183398.png\" alt=\"\u5149\u9057\u4f20\u5b66\" width=\"366\" height=\"230\" srcset=\"https:\/\/www.leadingtec.cn\/wp-content\/uploads\/2017\/03\/2016040514183398.png 366w, https:\/\/www.leadingtec.cn\/wp-content\/uploads\/2017\/03\/2016040514183398-300x189.png 300w\" sizes=\"auto, (max-width: 366px) 100vw, 366px\" \/><\/a><figcaption id=\"caption-attachment-4870\" class=\"wp-caption-text\"><\/span> <span style=\"font-size: 12pt;\">\u5149\u9057\u4f20\u5b66<\/span><\/figcaption><\/figure>\n<p><span style=\"font-size: 12pt;\">\u5927\u8111\u64cd\u7eb5\u672f\uff1a\u5728\u7b2c\u4e00\u4e2a\u5b9e\u9a8c\u4e2d\uff0c\u5c0f\u9f20\u89e6\u53ca\u5176\u4e2d\u4e00\u4e2a\u5149\u6e90\u4f1a\u83b7\u5f97\u6fc0\u5149\u6fc0\u53d1\u7684\u5feb\u611f\uff0c\u56e0\u6b64\u5c0f\u9f20\u4e3a\u4e86\u83b7\u5f97\u5956\u52b1\uff0c\u4f1a\u4e0d\u505c\u7684\u89e6\u53ca\u90a3\u4e2a\u5149\u6e90\uff1b\u5728\u7b2c\u4e8c\u4e2a\u5b9e\u9a8c\u4e2d\uff0c\u5c0f\u9f20\u542c\u5230\u8ba9\u5b83\u6050\u60e7\u7684\u58f0\u97f3\u65f6\uff0c\u4f1a\u7a81\u7136\u5446\u4f4f\uff0c\u5982\u679c\u6fc0\u5149\u523a\u6fc0\u7684\u533a\u57df\u4e0d\u80fd\u6fc0\u6d3b\u514b\u670d\u6050\u60e7\u7684\u533a\u57df\uff0c\u5c0f\u9f20\u4f1a\u4e00\u76f4\u4fdd\u6301\u9759\u6b62\uff1b\u5982\u679c\u6fc0\u5149\u523a\u6fc0\u7684\u533a\u57df\u6fc0\u6d3b\u4e86\u514b\u670d\u6050\u60e7\u7684\u533a\u57df\uff0c\u5c0f\u9f20\u4f1a\u7acb\u9a6c\u82e5\u65e0\u5176\u4e8b\u7684\u6d3b\u52a8\u8d77\u6765\uff0c\u5bf9\u6050\u60e7\u7684\u58f0\u97f3\u6ca1\u6709\u60e7\u6015\u7684\u8ff9\u8c61\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt;\">\u65e9\u57282002\u5e74\uff0c\u5fb7\u56fd\u79d1\u5b66\u5bb6Peter Hegemann\u56e2\u961f\u5728\u7eff\u85fb\u4e2d\u53d1\u73b0\u4e86\u4e00\u79cd\u86cb\u767d\u8d28\uff08Channelrhodopsin-1\uff09\uff0c\u8fd9\u79cd\u86cb\u767d\u8d28\u5206\u5e03\u5728\u7eff\u85fb\u7ec6\u80de\u7684\u8868\u9762\uff0c\u53ef\u4ee5\u5c06\u5149\u4fe1\u53f7\u8f6c\u6362\u6210\u7535\u4fe1\u53f7\uff0c\u6307\u5f15\u7eff\u85fb\u6e38\u52a8\u5230\u5149\u7ebf\u5145\u8db3\u7684\u5730\u65b9\u3002Hegemann\u56e2\u961f\u7684\u8fd9\u4e00\u91cd\u8981\u7814\u7a76\u6210\u679c\uff0c\u520a\u767b\u5728\u300a\u79d1\u5b66\u300b\u6742\u5fd7\u4e0a\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt;\">\u770b\u5230Hegemann\u56e2\u961f\u7684\u7814\u7a76\u6210\u679c\u4e4b\u540e\uff0cStanford\u795e\u7ecf\u79d1\u5b66\u5bb6Karl Deisseroth\u548c\u540c\u4e8bEdward Boyden\u840c\u751f\u7684\u7b2c\u4e00\u4e2a\u5ff5\u5934\u5c31\u662f\u628a\u8fd9\u79cd\u86cb\u767d\u5b9a\u5411\u8f6c\u5230\u52a8\u7269\u7684\u795e\u7ecf\u7ec6\u80de\u4e2d\uff0c\u8fd9\u6837\u5c31\u53ef\u4ee5\u901a\u8fc7\u5149\u7167\u7cbe\u51c6\u7684\u63a7\u5236\u5927\u8111\u7684\u6d3b\u52a8\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt;\">\u4e8e\u662f\uff0c\u5728Deisseroth\u3001Boyden\u548c\u5f20\u950b\u7684\u52aa\u529b\u4e0b\uff0c\u4ed6\u4eec\u7ec8\u4e8e\u5b9e\u73b0\u4e86\u7cbe\u51c6\u6fc0\u6d3b\u7279\u5b9a\u795e\u7ecf\u7ec6\u80de\u3002\u5149\u9057\u4f20\u5b66\u5c31\u8fd9\u6837\u8bde\u751f\u4e86\u30022011\u5e74\u300a\u81ea\u7136\u00b7\u65b9\u6cd5\u300b\u5c06\u5149\u9057\u4f20\u5b66\u9009\u4e3a\u5e74\u5ea6\u6280\u672f\uff0c2015\u5e74\u5e95\uff0cDeisseroth\u548cBoyden\u5171\u540c\u83b7\u5f97\u4e86\u751f\u547d\u79d1\u5b66\u91cd\u5927\u7a81\u7834\u5956\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt;\">\u867d\u7136\u5149\u9057\u4f20\u5b66\u6280\u672f\u5728\u5b9e\u9a8c\u5ba4\u91cc\u88ab\u5e94\u7528\u7684\u98ce\u751f\u6c34\u8d77\uff0c\u4f46\u662f\u9700\u8981\u5728\u88ab\u64cd\u7eb5\u7684\u5c0f\u9f20\u5927\u8111\u690d\u5165\u5149\u63a2\u5934\u548c\u5149\u7ea4\uff0c\u8fd9\u4e00\u70b9\u4e25\u91cd\u5236\u7ea6\u4e86\u5149\u9057\u4f20\u5b66\u6280\u672f\u7684\u4e34\u5e8a\u4f7f\u7528\u3002\u8fd9\u76f4\u63a5\u5bfc\u81f4\u5149\u9057\u4f20\u5b66\u4e00\u76f4\u88ab\u9650\u5236\u5728\u5b9e\u9a8c\u5ba4\u91cc\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt;\">2016\u5e74\uff0c\u5c31\u804c\u4e8e\u7f8e\u56fd\u97e6\u6069\u5dde\u7acb\u5927\u5b66\u548cRetroSense Therapeutics\u7684\u4e2d\u56fd\u79d1\u5b66\u5bb6\u6f58\u5353\u534e\u6559\u6388\uff0c\u4ee5\u53ca\u5176\u7814\u7a76\u56e2\u961f\u7ec8\u4e8e\u5c06\u8fd9\u4e00\u9769\u547d\u6027\u7684\u6280\u672f\u5e26\u5230\u4e86\u4e34\u5e8a\u3002<\/span><\/p>\n<figure id=\"attachment_4871\" aria-describedby=\"caption-attachment-4871\" style=\"width: 700px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/www.leadingtec.cn\/wp-content\/uploads\/2017\/03\/2016040514172264.png\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-4871\" src=\"https:\/\/www.leadingtec.cn\/wp-content\/uploads\/2017\/03\/2016040514172264.png\" alt=\"\u6f58\u5353\u534e\u6559\u6388\" width=\"700\" height=\"800\" srcset=\"https:\/\/www.leadingtec.cn\/wp-content\/uploads\/2017\/03\/2016040514172264.png 700w, https:\/\/www.leadingtec.cn\/wp-content\/uploads\/2017\/03\/2016040514172264-600x686.png 600w, https:\/\/www.leadingtec.cn\/wp-content\/uploads\/2017\/03\/2016040514172264-263x300.png 263w\" sizes=\"auto, (max-width: 700px) 100vw, 700px\" \/><\/a><figcaption id=\"caption-attachment-4871\" class=\"wp-caption-text\"><\/span> <span style=\"font-size: 12pt;\">\u6f58\u5353\u534e\u6559\u6388<\/span><\/figcaption><\/figure>\n<p><span style=\"font-size: 12pt;\">\u5728RetroSense Therapeutics\u6f58\u5353\u534e\u6559\u6388\u7684\u4e3b\u5bfc\u4e0b\uff0c2016\u5e742\u6708\u5e95\uff0c\u4e00\u540d\u56e0\u89c6\u7f51\u819c\u8272\u7d20\u53d8\u6027\uff08retinitis pigmentosa\uff0cRP\uff09\u4e27\u5931\u89c6\u529b\u7684Texas\u5973\u6027\uff0c\u5df2\u7ecf\u63a5\u53d7\u5149\u9057\u4f20\u5b66\u6cbb\u7597\uff0c\u6210\u4e3a\u5149\u9057\u4f20\u5b66\u6cbb\u7597\u7684\u5168\u7403\u7b2c\u4e00\u4eba\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt;\">RP\u662f\u4e00\u79cd\u5177\u6709\u660e\u663e\u9057\u4f20\u503e\u5411\u7684\u6162\u6027\u3001\u8fdb\u884c\u6027\u89c6\u7f51\u819c\u8272\u7d20\u4e0a\u76ae\u548c\u5149\u611f\u53d7\u5668\u7684\u53d8\u6027\u75be\u75c5\u3002\u76ee\u524d\u7684\u7814\u7a76\u8868\u660e\uff0c\u6709100\u591a\u79cd\u57fa\u56e0\u7a81\u53d8\u4f1a\u5f15\u8d77RP\u3002RP\u60a3\u8005\u7531\u4e8e\u611f\u5149\u7ec6\u80de\u53d7\u635f\uff0c\u65e0\u6cd5\u5c06\u5149\u4fe1\u53f7\u8f6c\u6362\u6210\u7535\u4fe1\u53f7\uff0c\u5e76\u901a\u8fc7\u795e\u7ecf\u4f20\u9012\u7ed9\u5927\u8111\uff0c\u6240\u4ee5\u770b\u4e0d\u89c1\u3002\u76ee\u524d\u56e0RP\u5f15\u8d77\u7684\u5931\u660e\u8fd8\u6ca1\u6709\u6709\u6548\u7684\u6cbb\u7597\u529e\u6cd5\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt;\">\u636e\u7edf\u8ba1\uff0c\u5728\u7f8e\u56fd\u6709\u8d85\u8fc7100\u4e07\u7684\u76f2\u4eba\uff0c\u5176\u4e2d\u7ea610\u4e07\u76f2\u4eba\u56e0\u4e3a\u89c6\u7f51\u819c\u8272\u7d20\u53d8\u6027\uff08retinitis pigmentosa\uff0cRP\uff09\u4e27\u5931\u89c6\u529b\u3002\u6839\u636e\u6211\u56fd\u90e8\u5206\u5730\u533a\u8c03\u67e5\u8d44\u6599\uff0cRP\u7fa4\u4f53\u60a3\u75c5\u7387\u7ea6\u4e3a1\/3500\uff0c\u603b\u60a3\u75c5\u4eba\u6570\u5e94\u8be5\u572840\u4e07\u4ee5\u4e0a\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt;\">\u5931\u660e\u7684\u5c0f\u9f20\u53ea\u7528\u901a\u8fc7\u4e0d\u505c\u5730\u6478\u7d22\uff0c\u624d\u80fd\u627e\u5230\u51fa\u53e3\u3002\u800c\u8bf1\u5bfc\u89c6\u7f51\u819c\u4e2d\u5176\u4ed6\u7ec6\u80de\u5177\u5907\u611f\u5149\u80fd\u529b\uff0c\u53ef\u4ee5\u4f7f\u56e0RP\u5931\u660e\u7684\u5c0f\u9f20\u611f\u53d7\u5230\u8db3\u591f\u7684\u5149\uff0c\u5e76\u8d70\u51fa\u8ff7\u5bab\u3002\u5c3d\u7ba1\u590d\u660e\u7684\u5c0f\u9f20\u6ca1\u6709\u529e\u6cd5\u544a\u8bc9\u7814\u7a76\u4eba\u5458\u5b83\u4eec\u770b\u5230\u4e86\u4ec0\u4e48\uff0c\u4f46\u662f\u4ece\u5b83\u4eec\u8eb2\u907f\u969c\u788d\u7684\u884c\u4e3a\u4e0a\u770b\uff0c\u5b83\u4eec\u771f\u662f\u770b\u89c1\u4e86\u3002<\/span><\/p>\n<p><span style=\"font-size: 12pt;\">RetroSense 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